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Carestia A, Kaufman T, Schattner M. Platelets: New Bricks in the Building of Neutrophil Extracellular Traps. Front Immunol. 2016;7:271doi: 10.3389/fimmu.2016.00271.
Carestia, A., Kaufman, T., & Schattner, M. (2016). Platelets: New Bricks in the Building of Neutrophil Extracellular Traps. Frontiers in immunology, 7271. https://doi.org/10.3389/fimmu.2016.00271
Carestia, Agostina, et al. "Platelets: New Bricks in the Building of Neutrophil Extracellular Traps." Frontiers in immunology vol. 7 (2016): 271. doi: https://doi.org/10.3389/fimmu.2016.00271
Carestia A, Kaufman T, Schattner M. Platelets: New Bricks in the Building of Neutrophil Extracellular Traps. Front Immunol. 2016 Jul 06;7:271. doi: 10.3389/fimmu.2016.00271. eCollection 2016. PMID: 27458459; PMCID: PMC4933697.
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Front Immunol. 2016 Jul 06;7:271. doi: 10.3389/fimmu.2016.00271. eCollection 2016.

Platelets: New Bricks in the Building of Neutrophil Extracellular Traps.

Frontiers in immunology

Agostina Carestia, Tomas Kaufman, Mirta Schattner

Affiliations

  1. Laboratory of Experimental Thrombosis, Institute of Experimental Medicine-CONICET, National Academy of Medicine , Buenos Aires , Argentina.

PMID: 27458459 PMCID: PMC4933697 DOI: 10.3389/fimmu.2016.00271

Abstract

In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens through the expression of toll-like receptors, the secretion of various cytokines, chemokines, and growth factors stored within their granules, and the expression of cell adhesion molecules that allows interaction with other immune cells, mainly neutrophils and monocytes. As part of the first line of defense, neutrophils control invading pathogens by phagocytosis, the release of antimicrobial proteins during degranulation, or through the formation of web-like structures named neutrophil extracellular traps (NETs). NETs are formed by chromatin, proteases, and antimicrobial proteins, and their main function is to trap and kill bacteria, virus, and fungi, avoiding their dissemination. Besides microorganisms, NET formation is also triggered by proinflammatory molecules and platelets. The uncontrolled formation of NETs might exert tissue damage and has been involved in a pathogenic mechanism of autoimmune and prothrombotic clinical conditions. In this review, we discuss the role of platelets in NET generation highlighting the mediators, stimuli, and molecular mechanisms involved in this phenomenon, both in human and murine models.

Keywords: inflammation; neutrophil extracellular traps; neutrophils; platelets; platelet–neutrophil interaction

References

  1. J Clin Invest. 2012 Jul;122(7):2661-71 - PubMed
  2. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):147-51 - PubMed
  3. Crit Care. 2012 Jul 26;16(4):R137 - PubMed
  4. Nat Rev Immunol. 2013 Jan;13(1):34-45 - PubMed
  5. PLoS Negl Trop Dis. 2015 Jul 10;9(7):e0003927 - PubMed
  6. J Thromb Haemost. 2014 Jun;12(6):860-70 - PubMed
  7. Front Immunol. 2014 Dec 18;5:649 - PubMed
  8. Blood. 2008 Sep 15;112(6):2327-35 - PubMed
  9. Blood. 2014 Apr 17;123(16):2573-84 - PubMed
  10. Cell Mol Life Sci. 2015 Jan;72(2):307-26 - PubMed
  11. Blood. 2011 Jan 20;117(3):953-9 - PubMed
  12. J Cell Biol. 2007 Jan 15;176(2):231-41 - PubMed
  13. Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6748-53 - PubMed
  14. J Thromb Haemost. 2012 Jan;10(1):136-44 - PubMed
  15. J Exp Med. 2000 Jul 17;192(2):193-204 - PubMed
  16. J Exp Med. 2012 Apr 9;209(4):819-35 - PubMed
  17. Cell Microbiol. 2006 Apr;8(4):668-76 - PubMed
  18. J Thromb Haemost. 2016 May;14(5):918-30 - PubMed
  19. Cell Host Microbe. 2012 Sep 13;12(3):324-33 - PubMed
  20. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):2032-40 - PubMed
  21. Blood. 2011 Sep 29;118(13):3708-14 - PubMed
  22. Blood. 2014 Jan 2;123(1):141-8 - PubMed
  23. Acta Cardiol. 2009 Feb;64(1):51-7 - PubMed
  24. Thromb Haemost. 2000 Dec;84(6):1087-94 - PubMed
  25. J Immunol. 2010 Dec 15;185(12):7413-25 - PubMed
  26. Nat Med. 2012 Sep;18(9):1386-93 - PubMed
  27. Cell Rep. 2014 Aug 7;8(3):883-96 - PubMed
  28. Annu Rev Immunol. 2011;29:139-62 - PubMed
  29. Blood. 2011 Aug 18;118(7):1952-61 - PubMed
  30. Blood. 2004 Mar 1;103(5):1602-10 - PubMed
  31. J Vasc Surg. 2016 Nov;64(5):1450-1458.e1 - PubMed
  32. J Exp Med. 2010 Aug 30;207(9):1853-62 - PubMed
  33. Cell Host Microbe. 2012 Jul 19;12(1):109-16 - PubMed
  34. Science. 2004 Mar 5;303(5663):1532-5 - PubMed
  35. Thromb Res. 2016 Mar;139:56-64 - PubMed
  36. Nat Med. 2007 Apr;13(4):463-9 - PubMed
  37. PLoS Negl Trop Dis. 2015 Jun 25;9(6):e0003869 - PubMed
  38. Cell Res. 2011 Feb;21(2):290-304 - PubMed
  39. Front Immunol. 2012 Oct 04;3:307 - PubMed
  40. J Leukoc Biol. 2016 Jan;99(1):153-62 - PubMed
  41. J Thromb Haemost. 2014 Dec;12(12):2074-88 - PubMed
  42. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2817-22 - PubMed
  43. Eur Heart J. 2015 Jun 7;36(22):1405-14 - PubMed
  44. Circulation. 2015 Feb 10;131(6):571-81 - PubMed
  45. Nat Chem Biol. 2011 Feb;7(2):75-7 - PubMed
  46. Blood. 2012 Jun 28;119(26):6335-43 - PubMed
  47. Int J Lab Hematol. 2013 Jun;35(3):254-61 - PubMed
  48. J Pharmacol Exp Ther. 2013 Jun;345(3):430-7 - PubMed
  49. J Thromb Haemost. 2016 Mar;14 (3):551-8 - PubMed
  50. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8674-9 - PubMed
  51. J Cell Biol. 2009 Jan 26;184(2):205-13 - PubMed
  52. Science. 2014 Dec 5;346(6214):1234-8 - PubMed
  53. Cell Host Microbe. 2013 Feb 13;13(2):169-80 - PubMed
  54. Blood. 2015 Jul 9;126(2):242-6 - PubMed
  55. Thromb Res. 2013 Mar;131(3):191-7 - PubMed
  56. Thromb Haemost. 2013 Nov;110(5):1035-45 - PubMed
  57. J Cell Biochem. 2013 Mar;114(3):532-40 - PubMed
  58. J Cell Biol. 2010 Nov 1;191(3):677-91 - PubMed
  59. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1382-9 - PubMed
  60. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15880-5 - PubMed
  61. Nat Immunol. 2014 Nov;15(11):1017-25 - PubMed
  62. J Immunol. 2012 Sep 15;189(6):2689-95 - PubMed
  63. Nat Med. 2009 Jun;15(6):623-5 - PubMed
  64. Platelets. 2015;26(4):286-92 - PubMed
  65. J Thromb Haemost. 2009 Nov;7(11):1759-66 - PubMed

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