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Hollis RL, Gourley C. Genetic and molecular changes in ovarian cancer. Cancer Biol Med. 2016;13(2):236-47doi: 10.20892/j.issn.2095-3941.2016.0024.
Hollis, R. L., & Gourley, C. (2016). Genetic and molecular changes in ovarian cancer. Cancer biology & medicine, 13(2), 236-47. https://doi.org/10.20892/j.issn.2095-3941.2016.0024
Hollis, Robert L, and Gourley, Charlie. "Genetic and molecular changes in ovarian cancer." Cancer biology & medicine vol. 13,2 (2016): 236-47. doi: https://doi.org/10.20892/j.issn.2095-3941.2016.0024
Hollis RL, Gourley C. Genetic and molecular changes in ovarian cancer. Cancer Biol Med. 2016 Jun;13(2):236-47. doi: 10.20892/j.issn.2095-3941.2016.0024. PMID: 27458531; PMCID: PMC4944549.
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Cancer Biol Med. 2016 Jun;13(2):236-47. doi: 10.20892/j.issn.2095-3941.2016.0024.

Genetic and molecular changes in ovarian cancer.

Cancer biology & medicine

Robert L Hollis, Charlie Gourley

Affiliations

  1. Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XR, UK.

PMID: 27458531 PMCID: PMC4944549 DOI: 10.20892/j.issn.2095-3941.2016.0024

Abstract

Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These subtypes represent distinct disease entities, both clinically and at the molecular level. Molecular analysis has revealed significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. As such, this subtype has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical implications. However, stratification of ovarian cancer patients based on the underlying biology of their disease remains in its infancy. Here, we summarize the molecular changes that characterize the five main ovarian cancer subtypes, highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research.

Keywords: Ovarian cancer; histological subtypes; molecular genetics; molecular subgrouping; ovary

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