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Park OJ, Han JS, Lee SH, et al. Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser. Ann Dermatol. 2016;28(4):457-63doi: 10.5021/ad.2016.28.4.457.
Park, O. J., Han, J. S., Lee, S. H., Park, C. S., Won, C. H., Lee, M. W., Choi, J. H., & Chang, S. E. (2016). Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser. Annals of dermatology, 28(4), 457-63. https://doi.org/10.5021/ad.2016.28.4.457
Park, Oun Jae, et al. "Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser." Annals of dermatology vol. 28,4 (2016): 457-63. doi: https://doi.org/10.5021/ad.2016.28.4.457
Park OJ, Han JS, Lee SH, Park CS, Won CH, Lee MW, Choi JH, Chang SE. Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser. Ann Dermatol. 2016 Aug;28(4):457-63. doi: 10.5021/ad.2016.28.4.457. Epub 2016 Jul 26. PMID: 27489428; PMCID: PMC4969475.
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Ann Dermatol. 2016 Aug;28(4):457-63. doi: 10.5021/ad.2016.28.4.457. Epub 2016 Jul 26.

Expression of Epidermal c-Kit+ of Vitiligo Lesions Is Related to Responses to Excimer Laser.

Annals of dermatology

Oun Jae Park, Ji Su Han, Sang Hyung Lee, Chan-Sik Park, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Sung Eun Chang

Affiliations

  1. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  2. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

PMID: 27489428 PMCID: PMC4969475 DOI: 10.5021/ad.2016.28.4.457

Abstract

BACKGROUND: The survival and growth of melanocytes are controlled by the binding of stem cell factor to its cell surface receptor c-kit+ (CD117). We have observed that c-kit+ melanocytes existed in some lesions of vitiligo, while Melan A+ cells were absent.

OBJECTIVE: To verify possible relation between c-kit+ expression and treatment response in non-segmental vitiligo lesions.

METHODS: Skin biopsies were done from the center of the 47 lesions from the 47 patients with non-segmental vitiligo. Expression of c-kit+ and Melan A, and amounts of melanin in the epidermis were assessed in each lesion, and treatment responses to excimer laser were evaluated.

RESULTS: Thirty-five of the 47 lesions (74.5%) had c-kit+ phenotypes. There was significant difference of c-kit staining value between good responders in 3 months of excimer laser treatment (average of 24 sessions) and the others.

CONCLUSION: c-Kit expression in vitiliginous epidermis may be related to better treatment responses to excimer laser.

Keywords: Excimer laser; Vitiligo; c-Kit receptor

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