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Márquez-Mota CC, Rodriguez-Gaytan C, Adjibade P, et al. The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein. Nutrients. 2016;8(9)doi: 10.3390/nu8090573.
Márquez-Mota, C. C., Rodriguez-Gaytan, C., Adjibade, P., Mazroui, R., Gálvez, A., Granados, O., Tovar, A. R., & Torres, N. (2016). The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein. Nutrients, 8(9), . https://doi.org/10.3390/nu8090573
Márquez-Mota, Claudia C, et al. "The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein." Nutrients vol. 8,9 (2016). doi: https://doi.org/10.3390/nu8090573
Márquez-Mota CC, Rodriguez-Gaytan C, Adjibade P, Mazroui R, Gálvez A, Granados O, Tovar AR, Torres N. The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein. Nutrients. 2016 Sep 20;8(9). doi: 10.3390/nu8090573. PMID: 27657118; PMCID: PMC5037558.
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Nutrients. 2016 Sep 20;8(9). doi: 10.3390/nu8090573.

The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein.

Nutrients

Claudia C Márquez-Mota, Cinthya Rodriguez-Gaytan, Pauline Adjibade, Rachid Mazroui, Amanda Gálvez, Omar Granados, Armando R Tovar, Nimbe Torres

Affiliations

  1. Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico. [email protected].
  2. Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico. [email protected].
  3. Centre de Recherche du Chu de Québec, Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Faculté de Médicine, Université Laval, Québec City, QC G1V 0A6, Canada. [email protected].
  4. Centre de Recherche du Chu de Québec, Département de Biologie Moléculaire, Biochimie Médicale et Pathologie, Faculté de Médicine, Université Laval, Québec City, QC G1V 0A6, Canada. [email protected].
  5. Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico. [email protected].
  6. Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico. [email protected].
  7. Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico. [email protected].
  8. Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México 14080, Mexico. [email protected].

PMID: 27657118 PMCID: PMC5037558 DOI: 10.3390/nu8090573

Abstract

Between 6% and 11% of the world's population suffers from malnutrition or undernutrition associated with poverty, aging or long-term hospitalization. The present work examined the effect of different types of proteins on the mechanistic target of rapamycin (mTORC1)-signaling pathway in: (1) healthy; and (2) protein restricted rats. (1) In total, 200 rats were divided into eight groups and fed one of the following diets: 20% casein (C), soy (S), black bean (B), B + Corn (BCr), Pea (P), spirulina (Sp), sesame (Se) or Corn (Cr). Rats fed C or BCr had the highest body weight gain; rats fed BCr had the highest pS6K1/S6K1 ratio; rats fed B, BCr or P had the highest eIF4G expression; (2) In total, 84 rats were fed 0.5% C for 21 day and protein rehabilitated with different proteins. The S, soy + Corn (SCr) and BCr groups had the highest body weight gain. Rats fed SCr and BCr had the highest eIF4G expression and liver polysome formation. These findings suggest that the quality of the dietary proteins modulate the mTORC1-signaling pathway. In conclusion, the combination of BCr or SCr are the best proteins for dietary protein rehabilitation due to the significant increase in body weight, activation of the mTORC1-signaling pathway in liver and muscle, and liver polysome formation.

Keywords: SNAT2; black bean protein; mTORC1-signaling pathway; polysome profiling; protein rehabilitation; soy protein

Conflict of interest statement

The authors declare no conflict of interest.

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