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Gulcicek OB, Solmaz A, Yiğitbaş H, et al. Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model. Gastroenterol Res Pract. 2016;2016:2081962doi: 10.1155/2016/2081962.
Gulcicek, O. B., Solmaz, A., Yiğitbaş, H., Ercetin, C., Yavuz, E., Ozdogan, K., Arici, S., Akkalp, A. K., Sarac, T., Çelebi, F., & Celik, A. (2016). Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model. Gastroenterology research and practice, 20162081962. https://doi.org/10.1155/2016/2081962
Gulcicek, Osman Bilgin, et al. "Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model." Gastroenterology research and practice vol. 2016 (2016): 2081962. doi: https://doi.org/10.1155/2016/2081962
Gulcicek OB, Solmaz A, Yiğitbaş H, Ercetin C, Yavuz E, Ozdogan K, Arici S, Akkalp AK, Sarac T, Çelebi F, Celik A. Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model. Gastroenterol Res Pract. 2016;2016:2081962. doi: 10.1155/2016/2081962. Epub 2016 Jul 21. PMID: 27525002; PMCID: PMC4972927.
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Gastroenterol Res Pract. 2016;2016:2081962. doi: 10.1155/2016/2081962. Epub 2016 Jul 21.

Comparison of the Effects of Glutamine, Curcumin, and Nesfatin-1 on the Gastric Serosal Surface Neomucosa Formation: An Experimental Rodent Model.

Gastroenterology research and practice

Osman Bilgin Gulcicek, Ali Solmaz, Hakan Yiğitbaş, Candas Ercetin, Erkan Yavuz, Kamil Ozdogan, Sinan Arici, Asli Kahraman Akkalp, Tulin Sarac, Fatih Çelebi, Atilla Celik

Affiliations

  1. Department of General Surgery, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
  2. Department of Pathology, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.
  3. Department of Biochemistry, Istanbul Bagcilar Training and Research Hospital, 34100 Istanbul, Turkey.

PMID: 27525002 PMCID: PMC4972927 DOI: 10.1155/2016/2081962

Abstract

Introduction. Short bowel syndrome can crop up if more than 50% of small intestine is resected or when less than 100 cm of small bowel is left. Glutamine is the main food source of enterocytes. Curcumin has protective effects on intestinal ischemia-reperfusion damage. Nesfatin-1 is a satiety molecule. It has protective effects on gastric mucosa. The primary purpose of this study is to compare effects of glutamine, curcumin, and nesfatin-1 on the gastric serosal surface neomucosa formation on rats. Materials and Methods. 24 Wistar-Hannover rats were randomly divided into 4 groups and treated with saline, glutamine, curcumin, and nesfatin-1 after ileogastric anastomosis. After 14 days all rats were euthanized, and blood was collected. En bloc resection of anastomotic part was performed for histopathological examination. Results. PDGF, TGF-β, and VEGF levels and neomucosa formation were higher in glutamine group (p = 0.003, p = 0.003, and p = 0.025). Glutamine promotes the intestinal neomucosa formation on the gastric serosal surface and augments growth factors essential for neomucosa formation on rats. Conclusion. Glutamine may be used in short bowel syndrome for increasing the absorption surface area. But that needs to be determined by adequately powered clinical trials.

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