Display options
Share it on

Ann Pediatr Cardiol. 2016 Sep-Dec;9(3):236-40. doi: 10.4103/0974-2069.189109.

Thromboembolism and anticoagulation after Fontan surgery.

Annals of pediatric cardiology

Sangeetha Viswanathan

Affiliations

  1. Department of Paediatric Cardiology, SRM Institute of Medical Sciences, Chennai, Tamil Nadu, India.

PMID: 27625521 PMCID: PMC5007932 DOI: 10.4103/0974-2069.189109

Abstract

This review attempts to answer the common questions faced by a clinician regarding thromboembolism and thromboprophylaxis in patients following Fontan surgery. The review is in an easy to understand question and answer format and discusses the currently available literature on the subject in an attempt to arrive at practical clinically relevant solutions. Patients who have undergone the Fontan operation are at a high risk for thromboembolism. Based on available evidence, there is a strong rationale for thromboprophylaxis. However, it is not clear as to which agent should be administered to prevent thromboembolic events. While the available evidence suggests that antiplatelet agents alone may be as good as oral anticoagulants, there is a need for a large multicenter randomized control trial comparing these two common strategies to deliver a clear verdict.

Keywords: Anticoagulation; Fontan; thromboembolism

References

  1. J Thorac Cardiovasc Surg. 2005 Mar;129(3):569-75 - PubMed
  2. Int J Cardiol. 2013 Oct 9;168(4):3940-3 - PubMed
  3. Am J Cardiol. 2016 Feb 1;117(3):450-5 - PubMed
  4. J Pediatr. 2012 Sep;161(3):513-519.e3 - PubMed
  5. J Am Coll Cardiol. 1991 Dec;18(7):1733-7 - PubMed
  6. J Thorac Cardiovasc Surg. 2003 Jun;125(6):1260-7 - PubMed
  7. Ann Thorac Surg. 2001 Jun;71(6):1990-4 - PubMed
  8. Ann Thorac Surg. 2002 Jun;73(6):1770-7 - PubMed
  9. Ann Thorac Surg. 1988 Mar;45(3):335-6 - PubMed
  10. Blood. 1999 Nov 1;94(9):3007-14 - PubMed
  11. J Am Coll Cardiol. 2003 Jun 18;41(12):2252-8 - PubMed
  12. J Am Coll Cardiol. 2013 Jan 22;61(3):346-53 - PubMed
  13. J Thorac Cardiovasc Surg. 2000 Apr;119(4 Pt 1):745-52 - PubMed
  14. Heart. 2004 Jul;90(7):825 - PubMed
  15. J Thorac Cardiovasc Surg. 2014 Dec;148(6):2517-23.e1 - PubMed
  16. J Am Coll Cardiol. 2011 Aug 2;58(6):645-51 - PubMed
  17. Ann Thorac Surg. 2002 Jan;73(1):64-8 - PubMed
  18. Pediatr Neurol. 1995 Apr;12(3):230-6 - PubMed
  19. J Thorac Cardiovasc Surg. 2002 Mar;123(3):459-65 - PubMed
  20. Ann Thorac Surg. 2009 Oct;88(4):1291-9 - PubMed
  21. J Am Coll Cardiol. 1991 Apr;17 (5):1152-60 - PubMed
  22. Ann Thorac Surg. 2002 Aug;74(2):556-62 - PubMed
  23. Circulation. 2014 Sep 9;130(11 Suppl 1):S32-8 - PubMed
  24. Heart. 2015 Nov;101(21):1731-7 - PubMed
  25. Circulation. 1995 Nov 1;92 (9 Suppl):II287-93 - PubMed
  26. Arch Dis Child. 1996 Mar;74(3):228-31 - PubMed
  27. Br Heart J. 1995 May;73(5):483-5 - PubMed
  28. Rev Esp Cardiol. 2002 Apr;55(4):449-51 - PubMed
  29. Am J Cardiol. 2004 Jan 1;93(1):117-9 - PubMed

Publication Types