Display options
Cite
Brock C, Brock B, Pedersen AG, et al. Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes. World J Diabetes. 2016;7(16):321-32doi: 10.4239/wjd.v7.i16.321.
Brock, C., Brock, B., Pedersen, A. G., Drewes, A. M., Jessen, N., & Farmer, A. D. (2016). Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes. World journal of diabetes, 7(16), 321-32. https://doi.org/10.4239/wjd.v7.i16.321
Brock, Christina, et al. "Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes." World journal of diabetes vol. 7,16 (2016): 321-32. doi: https://doi.org/10.4239/wjd.v7.i16.321
Brock C, Brock B, Pedersen AG, Drewes AM, Jessen N, Farmer AD. Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes. World J Diabetes. 2016 Aug 25;7(16):321-32. doi: 10.4239/wjd.v7.i16.321. PMID: 27625746; PMCID: PMC4999648.
Copy Download .nbib Format: NLM
Share it on

World J Diabetes. 2016 Aug 25;7(16):321-32. doi: 10.4239/wjd.v7.i16.321.

Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes.

World journal of diabetes

Christina Brock, Birgitte Brock, Anne Grave Pedersen, Asbjørn Mohr Drewes, Niels Jessen, Adam D Farmer

Affiliations

  1. Christina Brock, Anne Grave Pedersen, Asbjørn Mohr Drewes, Adam D Farmer, Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, DK-9000 Aalborg, Denmark.

PMID: 27625746 PMCID: PMC4999648 DOI: 10.4239/wjd.v7.i16.321

Abstract

The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal (GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between low-grade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes.

Keywords: Autonomic nervous system; Biomarkers; Diabetic neuropathy; Gastrointestinal dysmotility; Neuroinflammation

References

  1. J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S233-6 - PubMed
  2. Diabetologia. 1993 Jun;36(6):564-9 - PubMed
  3. J Intern Med. 2006 Apr;259(4):351-63 - PubMed
  4. Neurosci Lett. 2015 Jan 12;585:28-32 - PubMed
  5. Acta Diabetol. 2011 Jun;48(2):135-42 - PubMed
  6. PLoS One. 2015 Oct 12;10(10):e0138224 - PubMed
  7. Biol Psychol. 2009 Oct;82(2):101-10 - PubMed
  8. Diabetes Care. 2013 Nov;36(11):3698-705 - PubMed
  9. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E844-52 - PubMed
  10. Curr Diab Rep. 2014;14(9):527 - PubMed
  11. J Neurogastroenterol Motil. 2014 Apr 30;20(2):265-70 - PubMed
  12. Scand J Clin Lab Invest. 2012 Feb;72(1):1-13 - PubMed
  13. Circulation. 2006 Aug 8;114(6):597-605 - PubMed
  14. J Neurosci. 2014 Jun 25;34(26):8865-74 - PubMed
  15. Exp Diabetes Res. 2008;2008:457912 - PubMed
  16. Pediatr Diabetes. 2004 Mar;5(1):44-57 - PubMed
  17. Scand J Gastroenterol. 1996 Feb;31(2):136-9 - PubMed
  18. Neurogastroenterol Motil. 2014 Jan;26(1):46-58 - PubMed
  19. Diabetes Res Clin Pract. 2010 Jan;87(1):4-14 - PubMed
  20. Antioxid Redox Signal. 2013 Jun 10;18(17):2352-63 - PubMed
  21. Am J Gastroenterol. 2008 Mar;103(3):753-63 - PubMed
  22. J Intern Med. 1996 Feb;239(2):139-46 - PubMed
  23. Am J Physiol Endocrinol Metab. 2000 May;278(5):E759-68 - PubMed
  24. Int J Endocrinol. 2014;2014:674987 - PubMed
  25. Diabetologia. 1999 Sep;42(9):1120-30 - PubMed
  26. Therap Adv Gastroenterol. 2012 Jul;5(4):249-60 - PubMed
  27. Ann Gastroenterol. 2014;27(4):362-368 - PubMed
  28. Nat Rev Endocrinol. 2010 Feb;6(2):94-101 - PubMed
  29. PLoS One. 2012;7(8):e43919 - PubMed
  30. Diabetologia. 2015 Apr;58(4):666-77 - PubMed
  31. Front Endocrinol (Lausanne). 2014 Dec 01;5:205 - PubMed
  32. Diabetes. 1998 Jun;47(6):859-66 - PubMed
  33. Diabetes Care. 2010 Oct;33(10):2285-93 - PubMed
  34. Q J Med. 1980 Winter;49(193):95-108 - PubMed
  35. Clin Auton Res. 2009 Apr;19(2):79-87 - PubMed
  36. Am J Gastroenterol. 2001 Apr;96(4):1033-8 - PubMed
  37. Diabetes Care. 2008 Feb;31 Suppl 2:S170-80 - PubMed
  38. Diabetologia. 2003 Jul;46(7):934-9 - PubMed
  39. Gastroenterology. 2004 Nov;127(5):1592-622 - PubMed
  40. Diabetes. 2003 Jul;52(7):1799-805 - PubMed
  41. J Diabetes Investig. 2010 Jun 1;1(3):77-89 - PubMed
  42. Brain. 2005 May;128(Pt 5):1178-87 - PubMed
  43. Diabetologia. 2012 Jun;55(6):1856-62 - PubMed
  44. Clin Gastroenterol Hepatol. 2004 Sep;2(9):769-77 - PubMed
  45. Muscle Nerve. 2006 Jul;34(1):57-61 - PubMed
  46. Diabetologia. 2000 Aug;43(8):957-73 - PubMed
  47. Am J Obstet Gynecol. 1965 Aug 15;92:1140-8 - PubMed
  48. Arch Intern Med. 1990 Jun;150(6):1218-22 - PubMed
  49. Diabetes Care. 2006 Sep;29(9):2114-6 - PubMed
  50. Diabetes Care. 2010 Jun;33(6):1325-30 - PubMed
  51. Neurogastroenterol Motil. 2008 Apr;20(4):311-9 - PubMed
  52. Diabetes. 1993 Jun;42(6):801-13 - PubMed
  53. Diabet Med. 2014 Dec;31(12):1673-80 - PubMed
  54. United European Gastroenterol J. 2013 Dec;1(6):413-21 - PubMed

Publication Types