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Prud'homme S, Nevens F, Casteels I. Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals. GMS Ophthalmol Cases. 2016;6:Doc05doi: 10.3205/oc000042.
Prud'homme, S., Nevens, F., & Casteels, I. (2016). Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals. GMS ophthalmology cases, 6Doc05. https://doi.org/10.3205/oc000042
Prud'homme, Sylvie, et al. "Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals." GMS ophthalmology cases vol. 6 (2016): Doc05. doi: https://doi.org/10.3205/oc000042
Prud'homme S, Nevens F, Casteels I. Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals. GMS Ophthalmol Cases. 2016 Apr 04;6:Doc05. doi: 10.3205/oc000042. eCollection 2016. PMID: 27625964; PMCID: PMC5015795.
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GMS Ophthalmol Cases. 2016 Apr 04;6:Doc05. doi: 10.3205/oc000042. eCollection 2016.

Bilateral simultaneous anterior ischemic optic neuropathy, an extrahepatic manifestation of hepatitis C cured with direct acting antivirals.

GMS ophthalmology cases

Sylvie Prud'homme, Frederik Nevens, Ingele Casteels

Affiliations

  1. Division of Ophthalmology, University Hospitals KU Leuven, Leuven, Belgium.
  2. Division Liver and Biliopancreatic Disorders, University Hospitals KU Leuven, Leuven, Belgium.

PMID: 27625964 PMCID: PMC5015795 DOI: 10.3205/oc000042

Abstract

We report a patient with a bilateral optic anterior ischemic neuropathy as an extrahepatic complication of a chronic hepatitis C (HCV) infection. The patient presented with a bilateral visual acuity loss and bilateral optic disc oedema. The optic neuropathy was associated with a sudden increase in the viral HCV load after a recent liver transplantation. The stop of the calcineurin inhibitor had no effect on the course of the optic neuropathy. Visual improvement and normalization of HCV viraemia occurred after treatment with sofosbuvir and daclatasvir, which are direct acting antivirals.

Keywords: daclatasvir; hepatitis C; non arteritic ischemic optic neuropathy; sofosbuvir

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