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Brix N, Rasmussen F, Poletti V, et al. Eosinophil alveolitis in two patients with idiopathic pulmonary fibrosis. Respir Med Case Rep. 2016;19:61-4doi: 10.1016/j.rmcr.2016.07.010.
Brix, N., Rasmussen, F., Poletti, V., & Bendstrup, E. (2016). Eosinophil alveolitis in two patients with idiopathic pulmonary fibrosis. Respiratory medicine case reports, 1961-4. https://doi.org/10.1016/j.rmcr.2016.07.010
Brix, Ninna, et al. "Eosinophil alveolitis in two patients with idiopathic pulmonary fibrosis." Respiratory medicine case reports vol. 19 (2016): 61-4. doi: https://doi.org/10.1016/j.rmcr.2016.07.010
Brix N, Rasmussen F, Poletti V, Bendstrup E. Eosinophil alveolitis in two patients with idiopathic pulmonary fibrosis. Respir Med Case Rep. 2016 Jul 22;19:61-4. doi: 10.1016/j.rmcr.2016.07.010. eCollection 2016. PMID: 27625983; PMCID: PMC5010638.
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Respir Med Case Rep. 2016 Jul 22;19:61-4. doi: 10.1016/j.rmcr.2016.07.010. eCollection 2016.

Eosinophil alveolitis in two patients with idiopathic pulmonary fibrosis.

Respiratory medicine case reports

Ninna Brix, Finn Rasmussen, Venerino Poletti, Elisabeth Bendstrup

Affiliations

  1. Department of Respiratory Diseases and Allergology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus, Denmark.
  2. Department of Radiology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus, Denmark.

PMID: 27625983 PMCID: PMC5010638 DOI: 10.1016/j.rmcr.2016.07.010

Abstract

Bronchoalveolar lavage fluid (BALF) in patients with idiopathic pulmonary fibrosis (IPF) is typically characterized by a neutrophil inflammatory pattern and to a lesser extent (<25%) a mild eosinophil alveolitis. We here present two patients with a definite usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography of the thorax (HRCT) which demonstrated unusually high eosinophil counts in the BALF (40% and 51%). Based on HRCT, lack of response to steroids and the disease course they were both diagnosed as IPF after a multidisciplinary team discussion. This report discusses the diagnostic and etiological considerations of a coexisting UIP pattern and an eosinophil alveolitis. We conclude that these cases illustrate that high level BALF eosinophilia (40-50%) may occur among patients with IPF.

Keywords: Bronchoalveolar lavage; Eosinophilia; Idiopathic pulmonary fibrosis

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