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Int J Chron Obstruct Pulmon Dis. 2016 Sep 06;11:2125-2137. doi: 10.2147/COPD.S110504. eCollection 2016.

Application of the homology method for quantification of low-attenuation lung region inpatients with and without COPD.

International journal of chronic obstructive pulmonary disease

Mizuho Nishio, Kazuaki Nakane, Yutaka Tanaka

Affiliations

  1. Clinical PET Center, Institute of Biomedical Research and Innovation, Hyogo, Japan.
  2. Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan.
  3. Department of Radiology, Chibune General Hospital, Osaka, Japan.

PMID: 27660430 PMCID: PMC5019166 DOI: 10.2147/COPD.S110504

Abstract

BACKGROUND: Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema.

METHODS: This study included 112 patients who had undergone computed tomography and pulmonary function test. Low-attenuation lung regions were evaluated by the homology method, and homology-based emphysema quantification (

RESULTS: For forced expiratory volume in 1 second/forced vital capacity, the correlation coefficients were as follows: LAA%, -0.603;

CONCLUSION: Feasibility of the homology-based emphysema quantification was validated. The homology-based emphysema quantification was useful for the assessment of emphysema severity.

Keywords: COPD; emphysema; homology; low-attenuation lung region

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