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Muhammed J, Chen CY, Wan Hitam WH, et al. Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia. Malays J Med Sci. 2016;23(4):71-8doi: 10.21315/mjms2016.23.4.10.
Muhammed, J., Chen, C. Y., Wan Hitam, W. H., & Ghazali, M. Z. (2016). Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia. The Malaysian journal of medical sciences : MJMS, 23(4), 71-8. https://doi.org/10.21315/mjms2016.23.4.10
Muhammed, Julieana, et al. "Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia." The Malaysian journal of medical sciences : MJMS vol. 23,4 (2016): 71-8. doi: https://doi.org/10.21315/mjms2016.23.4.10
Muhammed J, Chen CY, Wan Hitam WH, Ghazali MZ. Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia. Malays J Med Sci. 2016 Jul;23(4):71-8. doi: 10.21315/mjms2016.23.4.10. Epub 2016 Jun 30. PMID: 27660548; PMCID: PMC5025066.
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Malays J Med Sci. 2016 Jul;23(4):71-8. doi: 10.21315/mjms2016.23.4.10. Epub 2016 Jun 30.

Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia.

The Malaysian journal of medical sciences : MJMS

Julieana Muhammed, Chui Yin Chen, Wan Hazabbah Wan Hitam, Mohamad Ziyadi Ghazali

Affiliations

  1. Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
  2. Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

PMID: 27660548 PMCID: PMC5025066 DOI: 10.21315/mjms2016.23.4.10

Abstract

BACKGROUND: A thymectomy is considered effective for patients with myasthenia gravis (MG). Although a few studies have described the role of a thymectomy in the treatment of MG in Asians countries, there are no published data on the application of this surgical approach for MG in Malaysia. We aimed to describe the clinical outcomes of MG patients who underwent a thymectomy and the factors affecting these outcomes.

METHODS: This was a retrospective study involving 16 patients with MG who underwent a thymectomy at the Hospital Universiti Sains Malaysia (HUSM) from January 2002 until December 2012, with a follow-up period ranging from 3-120 months.

RESULTS: The study consisted of 16 patients aged 22-78 years, 10 of whom were males. The overall remission/improvement rate was 87.5%, and the rate of clinical outcomes classified as unchanged/worsened was 12.5%. Thymomamatous or non-thymomamatous MG, histology features, Osserman stage and the duration of follow-up were not significant prognostic factors. Post-operative mortality was 6.2% (1 of 16 patients died of septic shock).

CONCLUSION: A thymectomy seems to be an effective treatment for MG, with low surgical morbidity. Patients with a lower Osserman stage and those with/without thymomas had favourable outcomes.

Keywords: myasthenia gravis; thymectomy; treatment outcomes

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