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de Oliveira GH, Cerni FA, Cardoso IA, et al. Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity. J Venom Anim Toxins Incl Trop Dis. 2016;22:26doi: 10.1186/s40409-016-0081-8.
de Oliveira, G. H., Cerni, F. A., Cardoso, I. A., Arantes, E. C., & Pucca, M. B. (2016). Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity. The journal of venomous animals and toxins including tropical diseases, 2226. https://doi.org/10.1186/s40409-016-0081-8
de Oliveira, Guilherme Honda, et al. "Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity." The journal of venomous animals and toxins including tropical diseases vol. 22 (2016): 26. doi: https://doi.org/10.1186/s40409-016-0081-8
de Oliveira GH, Cerni FA, Cardoso IA, Arantes EC, Pucca MB. Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity. J Venom Anim Toxins Incl Trop Dis. 2016 Sep 17;22:26. doi: 10.1186/s40409-016-0081-8. eCollection 2016. PMID: 27660634; PMCID: PMC5027101.
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J Venom Anim Toxins Incl Trop Dis. 2016 Sep 17;22:26. doi: 10.1186/s40409-016-0081-8. eCollection 2016.

Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity.

The journal of venomous animals and toxins including tropical diseases

Guilherme Honda de Oliveira, Felipe Augusto Cerni, Iara Aimê Cardoso, Eliane Candiani Arantes, Manuela Berto Pucca

Affiliations

  1. Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Av. do Café, s/n, 14040-903 Ribeirão Preto, SP Brazil.
  2. Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Av. do Café, s/n, 14040-903 Ribeirão Preto, SP Brazil ; Medical School of Roraima, Federal University of Roraima (UFRR), Av. Capitão Ene Garcez, 2413, Boa Vista, RR 69310-000 Brazil.

PMID: 27660634 PMCID: PMC5027101 DOI: 10.1186/s40409-016-0081-8

Abstract

BACKGROUND: In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations as mild, moderate or severe. Furthermore, the victims usually present biochemical alterations, including hyperglycemia. Nevertheless, Ts envenoming and its induced hyperglycemia were never studied or documented in a patient with diabetes mellitus (DM). Therefore, this is the first study to evaluate the glycemia during Ts envenoming using a diabetic animal model (NOD, non-obese diabetic).

METHODS: Female mice (BALB/c or NOD) were challenged with a non-lethal dose of Ts venom. Blood glucose level was measured (tail blood using a glucose meter) over a 24-h period. The total glycosylated hemoglobin (HbA1c) levels were measured 30 days after Ts venom injection. Moreover, the insulin levels were analyzed at the glycemia peak.

RESULTS: The results demonstrated that the envenomed NOD animals presented a significant increase of glycemia, glycosylated hemoglobin (HbA1c) and insulin levels compared to the envenomed BALB/c control group, corroborating that DM victims present great risk of developing severe envenoming. Moreover, the envenomed NOD animals presented highest risk of death and sequelae.

CONCLUSIONS: This study demonstrated that the diabetic victims stung by Ts scorpion should be always considered a risk group for scorpion envenoming severity.

Keywords: Diabetes mellitus; Glycemia; NOD mice; Scorpion venom; Tityus serrulatus

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