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McCombe A, Touma F, Jackson D, et al. Sudden cardiac death in adults with congenitally corrected transposition of the great arteries. Open Heart. 2016;3(2):e000407doi: 10.1136/openhrt-2016-000407.
McCombe, A., Touma, F., Jackson, D., Canniffe, C., Choudhary, P., Pressley, L., Tanous, D., Robinson, P. J., & Celermajer, D. (2016). Sudden cardiac death in adults with congenitally corrected transposition of the great arteries. Open heart, 3(2), e000407. https://doi.org/10.1136/openhrt-2016-000407
McCombe, A, et al. "Sudden cardiac death in adults with congenitally corrected transposition of the great arteries." Open heart vol. 3,2 (2016): e000407. doi: https://doi.org/10.1136/openhrt-2016-000407
McCombe A, Touma F, Jackson D, Canniffe C, Choudhary P, Pressley L, Tanous D, Robinson PJ, Celermajer D. Sudden cardiac death in adults with congenitally corrected transposition of the great arteries. Open Heart. 2016 Jul 11;3(2):e000407. doi: 10.1136/openhrt-2016-000407. eCollection 2016. PMID: 27493760; PMCID: PMC4947757.
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Open Heart. 2016 Jul 11;3(2):e000407. doi: 10.1136/openhrt-2016-000407. eCollection 2016.

Sudden cardiac death in adults with congenitally corrected transposition of the great arteries.

Open heart

A McCombe, F Touma, D Jackson, C Canniffe, P Choudhary, L Pressley, D Tanous, Peter J Robinson, D Celermajer

Affiliations

  1. Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Discipline of Medicine, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia.
  2. Department of Cardiology , Royal Prince Alfred Hospital , Sydney, New South Wales , Australia.
  3. Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Department of Cardiology, Mater Misericordiae Hospital, Dublin, Ireland.
  4. Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Discipline of Medicine, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia; Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia.

PMID: 27493760 PMCID: PMC4947757 DOI: 10.1136/openhrt-2016-000407

Abstract

BACKGROUND: Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital heart disease. There have been only few reports of sudden cardiac death (SCD) in patients with ccTGA and reasonable ventricular function.

METHODS: A retrospective review of the medical records of all patients attending our adult congenital heart centre, with known ccTGA.

RESULTS: From a database of over 3500 adult patients with congenital heart disease, we identified 39 (∼1%) with ccTGA and 'two-ventricle' circulations. 65% were male. The mean age at diagnosis was 12.4±11.4 years and the mean age at last time of review was 34.3±11.3 years. 24 patients (56%) had a history of surgical intervention. 8 (19%) had had pacemaker implantation and 2 had had a defibrillator implanted for non-sustained ventricular tachycardia (NSVT). In 544 years of patient follow-up, there had been five cases of SCD in our population; 1 death per 109 patient-years. Two of these patients had had previously documented supraventricular or NSVT. However, they were all classified as New York Heart Association (NYHA) class I or II, and systemic (right) ventricular function had been recorded as normal, mildly or mildly-moderately impaired, at most recent follow-up.

CONCLUSIONS: Our experience suggests the need for improved risk stratification and/or surveillance for malignant arrhythmia in adults with ccTGA, even in those with reasonable functional class on ventricular function.

Keywords: Cardiac arrhythmias and resuscitation science; Complex congenital heart disease

References

  1. Circulation. 1998 Sep 8;98(10):997-1005 - PubMed
  2. Circulation. 2012 Oct 16;126(16):1944-54 - PubMed
  3. Pediatr Cardiol. 1999 Nov-Dec;20(6):411-7 - PubMed
  4. Hum Pathol. 1995 Oct;26(10):1065-72 - PubMed
  5. Am J Epidemiol. 1985 Jan;121(1):31-6 - PubMed
  6. Can J Cardiol. 1996 May;12(5):526-8 - PubMed
  7. Pediatrics. 1980 Feb;65(2 Pt 2):375-461 - PubMed
  8. Indian Pacing Electrophysiol J. 2010 Apr 01;10(4):179-83 - PubMed
  9. J Interv Card Electrophysiol. 2004 Dec;11(3):211-5 - PubMed
  10. Eur Heart J. 2010 Dec;31(23):2915-57 - PubMed
  11. Am J Cardiol. 2000 Nov 15;86(10):1111-6 - PubMed
  12. Can J Cardiol. 1996 Nov;12(11):1161-3 - PubMed
  13. Am J Cardiol. 2011 Sep 1;108(5):729-34 - PubMed
  14. J Am Coll Cardiol. 2004 Sep 1;44(5):1095-102 - PubMed
  15. Am J Cardiol. 1986 Aug 1;58(3):319-24 - PubMed
  16. Circulation. 2002 Mar 12;105(10 ):1189-94 - PubMed
  17. Eur Heart J. 2010 May;31(10):1220-9 - PubMed
  18. J Invasive Cardiol. 2007 May;19(5):E139-41 - PubMed
  19. J Am Coll Cardiol. 1996 Apr;27(5):1238-43 - PubMed
  20. J Am Coll Cardiol. 2013 Sep 3;62(10 ):926-36 - PubMed
  21. J Am Coll Cardiol. 2000 Jul;36(1):255-61 - PubMed
  22. Circulation. 2006 Dec 12;114(24):2699-709 - PubMed
  23. Arch Mal Coeur Vaiss. 1979 Jan;72(1):113-7 - PubMed

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