Display options
Cite
Elbers LP, Boon HA, Moes MI, et al. Plasma Levels of Free Thyroxine and Risk of Major Bleeding in Bariatric Surgery. Eur Thyroid J. 2016;5(2):139-44doi: 10.1159/000446431.
Elbers, L. P., Boon, H. A., Moes, M. I., van Zaane, B., Brandjes, D. P., Fliers, E., Büller, H. R., Cannegieter, S., & Gerdes, V. E. (2016). Plasma Levels of Free Thyroxine and Risk of Major Bleeding in Bariatric Surgery. European thyroid journal, 5(2), 139-44. https://doi.org/10.1159/000446431
Elbers, Laura P B, et al. "Plasma Levels of Free Thyroxine and Risk of Major Bleeding in Bariatric Surgery." European thyroid journal vol. 5,2 (2016): 139-44. doi: https://doi.org/10.1159/000446431
Elbers LP, Boon HA, Moes MI, van Zaane B, Brandjes DP, Fliers E, Büller HR, Cannegieter S, Gerdes VE. Plasma Levels of Free Thyroxine and Risk of Major Bleeding in Bariatric Surgery. Eur Thyroid J. 2016 Jul;5(2):139-44. doi: 10.1159/000446431. Epub 2016 Jun 14. PMID: 27493889; PMCID: PMC4949359.
Copy Download .nbib Format: NLM
Share it on

Eur Thyroid J. 2016 Jul;5(2):139-44. doi: 10.1159/000446431. Epub 2016 Jun 14.

Plasma Levels of Free Thyroxine and Risk of Major Bleeding in Bariatric Surgery.

European thyroid journal

Laura P B Elbers, Hjalmar A Boon, Maaike I Moes, Bregje van Zaane, Dees P M Brandjes, Eric Fliers, Harry R Büller, Suzanne Cannegieter, Victor E A Gerdes

Affiliations

  1. Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Leiden, The Netherlands; Departments of, Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Leiden, The Netherlands.
  2. Department of Internal Medicine, Medical Center Slotervaart, University of Amsterdam, Leiden, The Netherlands.
  3. Departments of, Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, Leiden, The Netherlands.
  4. Departments of, Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Leiden, The Netherlands.
  5. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 27493889 PMCID: PMC4949359 DOI: 10.1159/000446431

Abstract

BACKGROUND: In a recent study of patients using vitamin K antagonists, those with low free thyroxin (FT4) levels within the normal range had a 3- to 5-fold increased risk of major bleeding. We tested the hypothesis that low levels of preoperative FT4 within the reference range are associated with an increased risk of major bleeding during and after bariatric surgery.

METHODS: The charts of 2,872 consecutive patients undergoing bariatric surgery were retrospectively screened for bleeding episodes. Patients with major bleeding until 1 month after surgery were compared to randomly selected control patients without bleeding, in a ratio of 1:4. We evaluated the association between preoperative FT4 levels and the risk of major bleeding by logistic regression.

RESULTS: Seventy-two cases (2.5%) with major bleeding were identified and 288 controls were selected. The median plasma level of FT4 was 13 pmol/l (interquartile range: 12-14) in the cases as well as in the controls. No clear effect was observed of low levels of FT4 on the risk of major bleeding: odds ratio 1.48 (95% CI: 0.46-4.80) for patients with an FT4 level <11 pmol/l, 1.03 (0.49-2.18) for patients with an FT4 level <12 pmol/l, and 1.12 (0.65-1.94) for patients with an FT4 level <13 pmol/l as compared to patients with FT4 values greater than or equal to these cutoff levels.

INTERPRETATION: We did not observe an increased risk of major bleeding with low levels of FT4 in patients undergoing bariatric surgery.

Keywords: Obesity; Surgery; Thyroid function; Thyroid hormone; Thyroid tests; Thyroxine

References

  1. Eur Thyroid J. 2014 Mar;3(1):32-7 - PubMed
  2. Eur J Endocrinol. 2009 Sep;161(3):459-65 - PubMed
  3. J Thromb Haemost. 2010 Jan;8(1):202-4 - PubMed
  4. Medicine (Baltimore). 2004 Mar;83(2):107-13 - PubMed
  5. Best Pract Res Clin Endocrinol Metab. 2009 Dec;23(6):753-67 - PubMed
  6. J Thromb Haemost. 2014 Jun;12(6):839-46 - PubMed
  7. J Clin Endocrinol Metab. 2001 Feb;86(2):732-7 - PubMed
  8. J Clin Endocrinol Metab. 2005 Jul;90(7):4019-24 - PubMed
  9. Haemophilia. 2014 May;20(3):326-32 - PubMed
  10. J Clin Endocrinol Metab. 2012 May;97(5):1554-62 - PubMed
  11. Thromb Res. 2012 Apr;129(4):520-2 - PubMed
  12. Thromb Haemost. 2003 Mar;89(3):493-8 - PubMed
  13. Postgrad Med J. 1990 Apr;66(774):280-4 - PubMed
  14. Clin Endocrinol (Oxf). 1997 May;46(5):587-98 - PubMed
  15. J Thromb Haemost. 2012 Aug;10(8):1539-46 - PubMed
  16. Blood. 2010 Jun 3;115(22):4344-9 - PubMed

Publication Types