Display options
Cite
Bądzyńska B, Lipkowski AW, Olszyński KH, et al. Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems. Can J Physiol Pharmacol. 2016;94(11):1159-1169doi: 10.1139/cjpp-2016-0111.
Bądzyńska, B., Lipkowski, A. W., Olszyński, K. H., & Sadowski, J. (2016). Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems. Canadian journal of physiology and pharmacology, 94(11), 1159-1169. https://doi.org/10.1139/cjpp-2016-0111
Bądzyńska, Bożena, et al. "Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems." Canadian journal of physiology and pharmacology vol. 94,11 (2016): 1159-1169. doi: https://doi.org/10.1139/cjpp-2016-0111
Bądzyńska B, Lipkowski AW, Olszyński KH, Sadowski J. Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems. Can J Physiol Pharmacol. 2016 Nov;94(11):1159-1169. doi: 10.1139/cjpp-2016-0111. Epub 2016 Jun 08. PMID: 27494747.
Copy Download .nbib Format: NLM
Share it on

Can J Physiol Pharmacol. 2016 Nov;94(11):1159-1169. doi: 10.1139/cjpp-2016-0111. Epub 2016 Jun 08.

Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems.

Canadian journal of physiology and pharmacology

Bożena Bądzyńska, Andrzej W Lipkowski, Krzysztof H Olszyński, Janusz Sadowski

Affiliations

  1. a Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawi?skiego St., 02-106 Warsaw, Poland.
  2. b Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawi?skiego St., 02-106 Warsaw, Poland.
  3. c Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, First Faculty of Medicine, Medical University of Warsaw, 1b Banacha St., 02-097, Warsaw, Poland.

PMID: 27494747 DOI: 10.1139/cjpp-2016-0111

Abstract

Opioids interact with sympathetic and renin-angiotensin systems in control of mean arterial pressure (MAP). Our earlier finding that biphalin, a synthetic enkephalin analogue, decreased MAP in anaesthetized spontaneously hypertensive rats (SHR) prompted us to further explore this action, to get new insights into pathogenesis of various forms of hypertension. Biphalin effects were studied in SHR, uninephrectomized rats on a high-salt diet (HS/UNX), and rats with angiotensin-induced hypertension (Ang-iH). Besides MAP, renal and iliac blood flows (RBF, IBF) and vascular resistances were measured. In anaesthetized and conscious SHR, biphalin (300 μg·h

Keywords: arterial blood pressure; biphalin; biphaline; modèles d’hypertension chez le rat; morphine; peripheral vascular resistance; rat hypertension models; renin–angiotensin system; résistance vasculaire périphérique; sympathetic nervous system; système nerveux sympathique; système rénine–angiotensine; tension artérielle

Publication Types