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Peng W, Chen Y, Ai W, et al. A Nanofluidic Biosensor Based on Nanoreplica Molding Photonic Crystal. Nanoscale Res Lett. 2016;11(1):427doi: 10.1186/s11671-016-1644-x.
Peng, W., Chen, Y., Ai, W., & Zhang, D. (2016). A Nanofluidic Biosensor Based on Nanoreplica Molding Photonic Crystal. Nanoscale research letters, 11(1), 427. https://doi.org/10.1186/s11671-016-1644-x
Peng, Wang, et al. "A Nanofluidic Biosensor Based on Nanoreplica Molding Photonic Crystal." Nanoscale research letters vol. 11,1 (2016): 427. doi: https://doi.org/10.1186/s11671-016-1644-x
Peng W, Chen Y, Ai W, Zhang D. A Nanofluidic Biosensor Based on Nanoreplica Molding Photonic Crystal. Nanoscale Res Lett. 2016 Dec;11(1):427. doi: 10.1186/s11671-016-1644-x. Epub 2016 Sep 23. PMID: 27664018; PMCID: PMC5035292.
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Nanoscale Res Lett. 2016 Dec;11(1):427. doi: 10.1186/s11671-016-1644-x. Epub 2016 Sep 23.

A Nanofluidic Biosensor Based on Nanoreplica Molding Photonic Crystal.

Nanoscale research letters

Wang Peng, Youping Chen, Wu Ai, Dailin Zhang

Affiliations

  1. School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
  2. Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
  3. Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
  4. School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. [email protected].

PMID: 27664018 PMCID: PMC5035292 DOI: 10.1186/s11671-016-1644-x

Abstract

A nanofluidic biosensor based on nanoreplica molding photonic crystal (PC) was proposed. UV epoxy PC was fabricated by nanoreplica molding on a master PC wafer. The nanochannels were sealed between the gratings on the PC surface and a taped layer. The resonance wavelength of PC-based nanofluidic biosensor was used for testing the sealing effect. According to the peak wavelength value of the sensor, an initial label-free experiment was realized with R6g as the analyte. When the PC-based biosensor was illuminated by a monochromatic light source with a specific angle, the resonance wavelength of the sensor will match with the light source and amplified the electromagnetic field. The amplified electromagnetic field was used to enhance the fluorescence excitation result. The enhancement effect was used for enhancing fluorescence excitation and emission when matched with the resonance condition. Alexa Fluor 635 was used as the target dye excited by 637-nm laser source on a configured photonic crystal enhanced fluorescence (PCEF) setup, and an initial PCEF enhancement factor was obtained.

Keywords: Nanochannels; Nanoreplica molding; Optofluidic biosensor; Photonic crystals

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