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Kumata K, Nagata K, Matsushita M, et al. Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation. Viral Immunol. 2016;29(8):459-463doi: 10.1089/vim.2016.0043.
Kumata, K., Nagata, K., Matsushita, M., Kuwamoto, S., Kato, M., Murakami, I., Fukata, S., & Hayashi, K. (2016). Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation. Viral immunology, 29(8), 459-463. https://doi.org/10.1089/vim.2016.0043
Kumata, Keisuke, et al. "Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation." Viral immunology vol. 29,8 (2016): 459-463. doi: https://doi.org/10.1089/vim.2016.0043
Kumata K, Nagata K, Matsushita M, Kuwamoto S, Kato M, Murakami I, Fukata S, Hayashi K. Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation. Viral Immunol. 2016 Oct;29(8):459-463. doi: 10.1089/vim.2016.0043. Epub 2016 Aug 16. PMID: 27529807; PMCID: PMC7307640.
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Viral Immunol. 2016 Oct;29(8):459-463. doi: 10.1089/vim.2016.0043. Epub 2016 Aug 16.

Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus Reactivation.

Viral immunology

Keisuke Kumata, Keiko Nagata, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Shuji Fukata, Kazuhiko Hayashi

Affiliations

  1. 1 Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University , Yonago, Japan .
  2. 2 Department of Pathology, Kochi Medical School , Nankoku, Japan .
  3. 3 Internal Medicine, Kuma Hospital , Kobe, Japan .

PMID: 27529807 PMCID: PMC7307640 DOI: 10.1089/vim.2016.0043

Abstract

Graves' disease is an autoimmune thyroid disorder that mainly presents as hyperthyroidism and is caused by thyrotropin receptor antibodies (TRAbs) that stimulate thyroid-stimulating hormone receptors. We previously reported that Graves' disease patients and healthy controls both had Epstein-Barr virus (EBV)-infected TRAb-positive B cells and the EBV-reactivated induction of these B cells in cultures may induce the production of TRAbs. In the present study, we quantified serum TRAb-IgG and TRAb-IgM levels in 34 Graves' disease patients and 15 controls using ELISA to elucidate the mechanisms underlying EBV-related antibody production. As expected, TRAb-IgG and TRAb-IgM levels were higher in Graves' disease patients than in controls; however, TRAb-IgM levels were significantly higher than those of TRAb-IgG levels, whereas total IgM levels were lower than total IgG levels. On the other hand, the enhanced production of TRAb-IgM was frequently observed in patients with EBV reactivation. These results are consistent with the fact that the percentage of autoreactive IgM B cells are higher than that of autoreactive IgG B cells, and support the EBV-related polyclonal B cell activation. It is necessary to clarify the biological characteristics of TRAb-IgM and the relationship between TRAb isotypes and the biology of Graves' disease.

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