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Davoodi P, Ng WC, Yan WC, et al. Double-Walled Microparticles-Embedded Self-Cross-Linked, Injectable, and Antibacterial Hydrogel for Controlled and Sustained Release of Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2016;8(35):22785-800doi: 10.1021/acsami.6b03041.
Davoodi, P., Ng, W. C., Yan, W. C., Srinivasan, M. P., & Wang, C. H. (2016). Double-Walled Microparticles-Embedded Self-Cross-Linked, Injectable, and Antibacterial Hydrogel for Controlled and Sustained Release of Chemotherapeutic Agents. ACS applied materials & interfaces, 8(35), 22785-800. https://doi.org/10.1021/acsami.6b03041
Davoodi, Pooya, et al. "Double-Walled Microparticles-Embedded Self-Cross-Linked, Injectable, and Antibacterial Hydrogel for Controlled and Sustained Release of Chemotherapeutic Agents." ACS applied materials & interfaces vol. 8,35 (2016): 22785-800. doi: https://doi.org/10.1021/acsami.6b03041
Davoodi P, Ng WC, Yan WC, Srinivasan MP, Wang CH. Double-Walled Microparticles-Embedded Self-Cross-Linked, Injectable, and Antibacterial Hydrogel for Controlled and Sustained Release of Chemotherapeutic Agents. ACS Appl Mater Interfaces. 2016 Sep 07;8(35):22785-800. doi: 10.1021/acsami.6b03041. Epub 2016 Aug 25. PMID: 27530316.
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ACS Appl Mater Interfaces. 2016 Sep 07;8(35):22785-800. doi: 10.1021/acsami.6b03041. Epub 2016 Aug 25.

Double-Walled Microparticles-Embedded Self-Cross-Linked, Injectable, and Antibacterial Hydrogel for Controlled and Sustained Release of Chemotherapeutic Agents.

ACS applied materials & interfaces

Pooya Davoodi, Wei Cheng Ng, Wei Cheng Yan, Madapusi P Srinivasan, Chi-Hwa Wang

Affiliations

  1. Department of Chemical and Biomolecular Engineering, National University of Singapore , 4 Engineering Drive 4, Singapore 117585.
  2. NUS Environmental Research Institute, National University of Singapore , 1 Create Way, Create Tower #15-02, Singapore 138602.
  3. Civil, Environmental and Chemical Engineering, RMIT University , GPO Box 2476, Melbourne Victoria 3001, Australia.

PMID: 27530316 DOI: 10.1021/acsami.6b03041

Abstract

First-line cancer chemotherapy has been prescribed for patients suffered from cancers for many years. However, conventional chemotherapy provides a high parenteral dosage of anticancer drugs over a short period, which may cause serious toxicities and detrimental side effects in healthy tissues. This study aims to develop a new drug delivery system (DDS) composed of double-walled microparticles and an injectable hydrogel for localized dual-agent drug delivery to tumors. The uniform double-walled microparticles loaded with cisplatin (Cis-DDP) and paclitaxel (PTX) were fabricated via coaxial electrohydrodynamic atomization (CEHDA) technique and subsequently were embedded into injectable alginate-branched polyethylenimine. The findings show the uniqueness of CEHDA technique for simply swapping the place of drugs to achieve a parallel or a sequential release profile. This study also presents the simulation of CEHDA technique using computational fluid dynamics (CFD) that will help in the optimization of CEHDA's operating conditions prior to large-scale production of microparticles. The new synthetic hydrogel provides an additional diffusion barrier against Cis-DDP and confines premature release of drugs. In addition, the hydrogel can provide a versatile tool for retaining particles in the tumor resected cavity during the injection after debulking surgery and preventing surgical site infection due to its inherent antibacterial properties. Three-dimensional MDA-MB-231 (breast cancer) spheroid studies demonstrate a superior efficacy and a greater reduction in spheroid growth for drugs released from the proposed composite formulation over a prolonged period, as compared with free drug treatment. Overall, the new core-shell microparticles embedded into injectable hydrogel can serve as a flexible controlled release platform for modulating the release profiles of anticancer drugs and subsequently providing a superior anticancer response.

Keywords: 3D tumor spheroids; antibacterial surfaces; core−shell microparticles; dual-agent drug delivery; injectable hydrogels

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