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Mahshidfar B, Sameti A, Abbasi S, et al. Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?. Indian J Crit Care Med. 2016;20(8):465-8doi: 10.4103/0972-5229.188197.
Mahshidfar, B., Sameti, A., Abbasi, S., Farsi, D., Mofidi, M., Hafezimoghadam, P., Rahimzadeh, P., & Rezai, M. (2016). Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 20(8), 465-8. https://doi.org/10.4103/0972-5229.188197
Mahshidfar, Babak, et al. "Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?." Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine vol. 20,8 (2016): 465-8. doi: https://doi.org/10.4103/0972-5229.188197
Mahshidfar B, Sameti A, Abbasi S, Farsi D, Mofidi M, Hafezimoghadam P, Rahimzadeh P, Rezai M. Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?. Indian J Crit Care Med. 2016 Aug;20(8):465-8. doi: 10.4103/0972-5229.188197. PMID: 27630458; PMCID: PMC4994126.
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Indian J Crit Care Med. 2016 Aug;20(8):465-8. doi: 10.4103/0972-5229.188197.

Can intravenous acetaminophen reduce the needs to more opioids to control pain in intubated patients?.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Babak Mahshidfar, Azadeh Sameti, Saeed Abbasi, Davood Farsi, Mani Mofidi, Peyman Hafezimoghadam, Popak Rahimzadeh, Mahdi Rezai

Affiliations

  1. Emergency Medicine Management Research Center, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  2. Department of Anesthesiology, Rasoul-e-Akram Hospital, Iran university of Medical Sciences, Tehran, Iran.

PMID: 27630458 PMCID: PMC4994126 DOI: 10.4103/0972-5229.188197

Abstract

AIMS: To evaluate the effect of intravenous (IV) acetaminophen on reducing the need for morphine sulfate in intubated patients admitted to the Intensive Care Unit (ICU).

SETTINGS AND DESIGN: Current study was done as a clinical trial on the patients supported by mechanical ventilator.

SUBJECTS AND METHODS: Behavioral pain scale (BPS) scoring system was used to measure pain in the patients. All of the patients received 1 g, IV acetaminophen, every 6 h during the 1(st) and 3(rd) days of admission and placebo during the 2(nd) and 4(th) days. Total dose of morphine sulfate needed, its complications, and the BPS scores at the end of every 6 h interval were compared.

RESULTS: Totally forty patients were enrolled. The mean pain scores were significantly lower in the 2(nd) and 4(th) days (4.33 and 3.66, respectively; mean: 4.0) in which the patients had received just morphine sulfate compared to the 1(st) and 3(rd) days (7.36 and 3.93, respectively; mean: 5.65) in which the patients had received acetaminophen in addition to morphine sulfate too (P < 0.001). Cumulative dose of morphine sulfate used, was significantly higher in the 1(st) and 3(rd) days (8.92 and 3.15 mg, respectively; 12.07 mg in total) compared to the 2(nd) and 4(th) days (6.47 mg and 3.22 mg, respectively; 9.7 mg in total) (P = 0.035).

CONCLUSION: In our study, IV acetaminophen had no effect on decreasing the BPSs and need of morphine sulfate in intubated patients admitted to ICU.

Keywords: Acetaminophen; Intensive Care Unit; analgesia; intubated patient; morphine sulfate; pain

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