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Rajkumar P, Mathew BS, Das S, et al. Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery. J Clin Diagn Res. 2016;10(7):XC01-XC04doi: 10.7860/JCDR/2016/18181.8126.
Rajkumar, P., Mathew, B. S., Das, S., Isaiah, R., John, S., Prabha, R., & Fleming, D. H. (2016). Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery. Journal of clinical and diagnostic research : JCDR, 10(7), XC01-XC04. https://doi.org/10.7860/JCDR/2016/18181.8126
Rajkumar, Pradeep, et al. "Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery." Journal of clinical and diagnostic research : JCDR vol. 10,7 (2016): XC01-XC04. doi: https://doi.org/10.7860/JCDR/2016/18181.8126
Rajkumar P, Mathew BS, Das S, Isaiah R, John S, Prabha R, Fleming DH. Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery. J Clin Diagn Res. 2016 Jul;10(7):XC01-XC04. doi: 10.7860/JCDR/2016/18181.8126. Epub 2016 Jul 01. PMID: 27630935; PMCID: PMC5020194.
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J Clin Diagn Res. 2016 Jul;10(7):XC01-XC04. doi: 10.7860/JCDR/2016/18181.8126. Epub 2016 Jul 01.

Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery.

Journal of clinical and diagnostic research : JCDR

Pradeep Rajkumar, Binu Susan Mathew, Saikat Das, Rajesh Isaiah, Subashini John, Ratna Prabha, Denise Helen Fleming

Affiliations

  1. Fellow, Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology, Christian Medical College Hospital , Vellore, India .
  2. Professor, Clinical Pharmacology Unit, Department of Pharmacology and Clinical Pharmacology, Christian Medical College Hospital , Vellore, India .
  3. Associate Professor, Department of Radiation Oncology, Christian Medical College Hospital , Vellore, India .
  4. Professor, Department of Radiation Oncology, Christian Medical College Hospital , Vellore, India .
  5. Assistant Professor, Clinical Pharmacology Unit, Christian Medical College Hospital , Vellore, India .
  6. Professor, Clinical Pharmacology Unit, Christian Medical College Hospital , Vellore, India .

PMID: 27630935 PMCID: PMC5020194 DOI: 10.7860/JCDR/2016/18181.8126

Abstract

INTRODUCTION: Cisplatin has radiosensitizing properties and the best sensitization to radiotherapy occurs with a higher plasma concentration of cisplatin. To our knowledge the optimal time sequence between chemotherapy and administration of radiation therapy, to obtain maximum effect from concurrent chemoradiation is unclear.

AIM: The aim of this study was to measure the two cisplatin infusion regimens in order to determine the total and free cisplatin post infusion concentration changes over time. These changes may have clinical implications on the optimum time of administration of post infusion radiation therapy.

MATERIALS AND METHODS: Two cohorts of patients were recruited and both, total and free plasma concentration of cisplatin following long and short durations of intravenous infusion was determined. Blood samples were collected at 0.5, 1, 1.5, 2, 3 and 5 hours from the start of the infusion in the 1hour infusion group and at 2, 3, 3.5, 4, 6 and 24 hours from the start of the infusion, in the 3 hour infusion group. Total and free cisplatin concentrations were measured using a validated HPLC-UV method.

RESULTS: The highest concentration of total and free cisplatin was achieved at the end of the infusion in both regimens. Total cisplatin concentration declined 30 minutes after the end of infusion in both the groups. After 1hour of discontinuing cisplatin, the free cisplatin concentration also declined significantly.

CONCLUSION: We conclude that radiation should be administered within 30 minutes of completion of the infusion irrespective of the duration of infusion.

Keywords: Chemotherapy; Radiation therapy; Radiosensitizing

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