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Mohan SP, Chitturi RT, Ragunathan YT, et al. Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study. J Clin Diagn Res. 2016;10(7):ZC12-5doi: 10.7860/JCDR/2016/20218.8116.
Mohan, S. P., Chitturi, R. T., Ragunathan, Y. T., Lakshmi, S. J., Nallusamy, J., & Joseph, I. (2016). Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study. Journal of clinical and diagnostic research : JCDR, 10(7), ZC12-5. https://doi.org/10.7860/JCDR/2016/20218.8116
Mohan, Sunil Paramel, et al. "Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study." Journal of clinical and diagnostic research : JCDR vol. 10,7 (2016): ZC12-5. doi: https://doi.org/10.7860/JCDR/2016/20218.8116
Mohan SP, Chitturi RT, Ragunathan YT, Lakshmi SJ, Nallusamy J, Joseph I. Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study. J Clin Diagn Res. 2016 Jul;10(7):ZC12-5. doi: 10.7860/JCDR/2016/20218.8116. Epub 2016 Jul 01. PMID: 27630945; PMCID: PMC5020236.
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J Clin Diagn Res. 2016 Jul;10(7):ZC12-5. doi: 10.7860/JCDR/2016/20218.8116. Epub 2016 Jul 01.

Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study.

Journal of clinical and diagnostic research : JCDR

Sunil Paramel Mohan, Ravi Teja Chitturi, Yoithapprabhunath Thukanayakanpalayam Ragunathan, Suman Jhansi Lakshmi, Jaisanghar Nallusamy, Isaac Joseph

Affiliations

  1. Head of Department, Deparment of Oral Pathology, Director, Department of Stem Cells and Regenerative Medicine, Dean, Sree Anjaneya Institute of Dental Sciences , Calicut, Kerala, India .
  2. Lecturer, Department of Oral Biology, School of Dentistry, Faculty of Medical Sciences, The University of the West Indies , St. Augustine Campus, Trinidad and Tobago .
  3. Reader, Department of Oral and Maxillofacial Pathology, Vivekanandha Dental College for Women , Tamilnadu, India .
  4. Professor, Department of Oral Medicine and Radiology, K S R Institute of Dental Science and Research , Tiruchengode, Tamilnadu, India .
  5. Professor, Department of Oral Medicine and Radiology, Sree Anjaneya Institute of Dental Sciences , Calicut, Kerala, India .
  6. Professor and Head, Department of Oral Pathology, Sree Moogambigai Dental College , Kulasekharam, Tamil Nadu, India .

PMID: 27630945 PMCID: PMC5020236 DOI: 10.7860/JCDR/2016/20218.8116

Abstract

INTRODUCTION: The most common etiology for Oral Squamous Cell Carcinoma (OSCC) is tobacco and tobacco related products which cause nuclear damage to the keratinocytes. The chemical carcinogens not only affect the lining of oral epithelium but also affect the lining epithelium of the excretory ducts of the salivary glands. Thus, there is a possibility of epithelial dysplasia of the salivary duct epithelium which may lead to potential malignant transformation.

AIM: The study was performed to see the changes in the minor salivary glands and excretory ducts in cases of oral epithelial dysplasia and OSCC.

MATERIALS AND METHODS: A total of 278 archival cases of mild, moderate and severe epithelial dysplasia, carcinoma in situ, OSCC including verrucous carcinoma were histopathologically evaluated to observe changes in the excretory ducts and the minor salivary glands.

RESULTS: In the study there were 56.5% males and 43.5% females. The age group that was most commonly affected in both the sexes was 50-60 yr old. Buccal mucosa was the most common site of involvement. Ductal changes observed in the excretory duct include simple hyperplasia, metaplastic changes such as mucous, oncocytic & squamous, and infiltration of inflammatory cells and malignant cells. Acinar changes observed were degeneration, squamous metaplasia, myoepithelial cell proliferation and inflammatory cell infiltration. Both the excretory ducts and ducts within the gland showed dysplasia.

CONCLUSION: According to observations in our study it is suggested that histopathological interpretation for oral mucosal lesions especially oral epithelial dysplasias and OSCC should also include changes related to salivary gland tissue to provide a better treatment plan and prevent recurrence of the malignant tumours.

Keywords: Acinar changes; Excretory duct; Hyperplasia; Metaplasia; Salivary gland tumour

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