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Northoff G, Duncan NW. How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology. Prog Neurobiol. 2016;145:26-45doi: 10.1016/j.pneurobio.2016.08.003.
Northoff, G., & Duncan, N. W. (2016). How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology. Progress in neurobiology, 14526-45. https://doi.org/10.1016/j.pneurobio.2016.08.003
Northoff, Georg, and Duncan, Niall W. "How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology." Progress in neurobiology vol. 145 (2016): 26-45. doi: https://doi.org/10.1016/j.pneurobio.2016.08.003
Northoff G, Duncan NW. How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology. Prog Neurobiol. 2016 Oct - Nov;145:26-45. doi: 10.1016/j.pneurobio.2016.08.003. Epub 2016 Aug 12. PMID: 27531135.
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Prog Neurobiol. 2016 Oct - Nov;145:26-45. doi: 10.1016/j.pneurobio.2016.08.003. Epub 2016 Aug 12.

How do abnormalities in the brain's spontaneous activity translate into symptoms in schizophrenia? From an overview of resting state activity findings to a proposed spatiotemporal psychopathology.

Progress in neurobiology

Georg Northoff, Niall W Duncan

Affiliations

  1. Mental Health Centre, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; University of Ottawa Institute of Mental Health Research and University of Ottawa Brain and Mind Research Institute, Ottawa, Canada; Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China; Brain and Consciousness Research Centre, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: [email protected].
  2. Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China; Brain and Consciousness Research Centre, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei, Taiwan.

PMID: 27531135 DOI: 10.1016/j.pneurobio.2016.08.003

Abstract

Schizophrenia is a complex neuropsychiatric disorder with a variety of symptoms that include sensorimotor, affective, cognitive, and social changes. The exact neuronal mechanisms underlying these symptoms remain unclear though. Neuroimaging has focused mainly on the brain's extrinsic activity, specifically task-evoked or stimulus-induced activity, as related to the sensorimotor, affective, cognitive, and social functions. Recently, the focus has shifted to the brain's spontaneous activity, otherwise known as its resting state activity. While various spatial and temporal abnormalities have been observed in spontaneous activity in schizophrenia, their meaning and significance for the different psychopathological symptoms in schizophrenia, are yet to be defined. The first aim in this paper is to provide an overview of recent findings concerning changes in the spatial (e.g., functional connectivity) and temporal (e.g., couplings between different frequency fluctuations) properties of spontaneous activity in schizophrenia. The second aim is to link these spatiotemporal changes to the various psychopathological symptoms of schizophrenia, with a specific focus on basic symptoms, formal thought disorder, and ego-disturbances. Based on the various findings described, we postulate that the spatiotemporal changes on the neuronal level of the brain's spontaneous activity transform into corresponding spatiotemporal changes on the psychological level which, in turn, leads to the different kinds of psychopathological symptoms. We consequently suggest a spatiotemporal rather than cognitive or sensory approach to the condition, amounting to what we describe as "Spatiotemporal Psychopathology".

Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords: Cross-frequency coupling; Functional connectivity; Intrinsic activity; Resting-state; Schizophrenia; Temporal structure

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