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Yun JW, Xiao A, Tsunoda I, et al. From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases. Pathophysiology. 2016;23(4):265-274doi: 10.1016/j.pathophys.2016.08.004.
Yun, J. W., Xiao, A., Tsunoda, I., Minagar, A., & Alexander, J. S. (2016). From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases. Pathophysiology : the official journal of the International Society for Pathophysiology, 23(4), 265-274. https://doi.org/10.1016/j.pathophys.2016.08.004
Yun, J Winny, et al. "From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 23,4 (2016): 265-274. doi: https://doi.org/10.1016/j.pathophys.2016.08.004
Yun JW, Xiao A, Tsunoda I, Minagar A, Alexander JS. From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases. Pathophysiology. 2016 Dec;23(4):265-274. doi: 10.1016/j.pathophys.2016.08.004. Epub 2016 Aug 12. PMID: 27531185.
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Pathophysiology. 2016 Dec;23(4):265-274. doi: 10.1016/j.pathophys.2016.08.004. Epub 2016 Aug 12.

From trash to treasure: The untapped potential of endothelial microparticles in neurovascular diseases.

Pathophysiology : the official journal of the International Society for Pathophysiology

J Winny Yun, Adam Xiao, Ikuo Tsunoda, Alireza Minagar, J Steven Alexander

Affiliations

  1. Departments of Molecular & Cellular Physiology, LSU Health Sciences Center, Shreveport, LA, United States.
  2. Departments of Neurology, LSU Health Sciences Center, Shreveport, LA, United States; Department of Microbiology, Kindai University, Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan.
  3. Departments of Neurology, LSU Health Sciences Center, Shreveport, LA, United States.
  4. Departments of Molecular & Cellular Physiology, LSU Health Sciences Center, Shreveport, LA, United States; Departments of Neurology, LSU Health Sciences Center, Shreveport, LA, United States. Electronic address: [email protected].

PMID: 27531185 DOI: 10.1016/j.pathophys.2016.08.004

Abstract

Discovered in 1947, microparticles (MP) represent a group of sub-micron cell-derived particles isolated by high speed centrifugation. Once regarded as cellular 'trash', in the past decade MP have gained tremendous attention in both basic sciences and medical research both as biomarkers and mediators of infection, injury and response to therapy. Because MP bear cell surface markers derived from parent cells, accumulate in extracellular fluids (plasma, serum, milk, urine, cerebrospinal fluid) MP based tests are being developed commercially as important components in 'liquid biopsy' approaches, providing valuable readouts in cardiovascular disease and cancer, as well as stroke, Alzheimer's disease and Multiple Sclerosis. Importantly, MP have been reported as mobile transport vectors in the intercellular transfer of mRNAs, microRNAs, lipids and proteins. Here we discuss MP structure, properties and functions with particular relevance to neurological and neurovascular diseases.

Copyright © 2016 Elsevier B.V. All rights reserved.

Keywords: Alzheimer’s; Endothelial; Multiple sclerosis; Platelet

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