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Högfeldt T, Jaing C, Loughlin KM, et al. Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions. Oncol Lett. 2016;12(4):2782-2788doi: 10.3892/ol.2016.5012.
Högfeldt, T., Jaing, C., Loughlin, K. M., Thissen, J., Gardner, S., Bahnassy, A. A., Gharizadeh, B., Lundahl, J., Österborg, A., Porwit, A., Zekri, A. N., Khaled, H. M., Mellstedt, H., & Moshfegh, A. (2016). Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions. Oncology letters, 12(4), 2782-2788. https://doi.org/10.3892/ol.2016.5012
Högfeldt, Therese, et al. "Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions." Oncology letters vol. 12,4 (2016): 2782-2788. doi: https://doi.org/10.3892/ol.2016.5012
Högfeldt T, Jaing C, Loughlin KM, Thissen J, Gardner S, Bahnassy AA, Gharizadeh B, Lundahl J, Österborg A, Porwit A, Zekri AN, Khaled HM, Mellstedt H, Moshfegh A. Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions. Oncol Lett. 2016 Oct;12(4):2782-2788. doi: 10.3892/ol.2016.5012. Epub 2016 Aug 16. PMID: 27698858; PMCID: PMC5038175.
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Oncol Lett. 2016 Oct;12(4):2782-2788. doi: 10.3892/ol.2016.5012. Epub 2016 Aug 16.

Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions.

Oncology letters

Therese Högfeldt, Crystal Jaing, Kevin Mc Loughlin, James Thissen, Shea Gardner, Abeer A Bahnassy, Baback Gharizadeh, Joachim Lundahl, Anders Österborg, Anna Porwit, Abdel-Rahman N Zekri, Hussein M Khaled, Håkan Mellstedt, Ali Moshfegh

Affiliations

  1. Department of Oncology and Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
  2. Chemistry, Materials, Earth and Life Sciences, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  3. Computation, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.
  4. Department of Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
  5. Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.
  6. Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden.
  7. Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
  8. Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.

PMID: 27698858 PMCID: PMC5038175 DOI: 10.3892/ol.2016.5012

Abstract

Diffuse large B-cell lymphoma (DLBCL), the most common type of non-Hodgkin's lymphoma (NHL) in adults, accounts for approximately 30-40% of newly diagnosed lymphomas worldwide. Environmental factors, such as viruses and bacteria, may contribute to cancer development through chronic inflammation and the integration of oncogenes, and have previously been indicated in cervical cancer, hepatocellular carcinoma, gastric cancer and lymphoproliferative disorders. In the present study, the presence of microbial agents was analyzed in the lymphoma tissue of patients with activated B-cell like (ABC) DLBCL. The present study compared two groups of patients from geographically varied regions that possess a difference in the prevalence of viral and other microbial agents. The patient populations were from Sweden (a low endemic infectious disease region) and Egypt (a high endemic infectious disease region). A differential expression of several viruses in lymphoma tissues was noted when comparing Swedish and Egyptian patients. JC polyomavirus (JCV) was detected in Swedish and Egyptian patients and, uniquely, the complete hepatitis B virus (HBV) genome was detected only in Egyptian lymphoma patients. None of these viruses were detected in control lymph tissues from Sweden or Egypt. In total, 38% of the Egyptian patients were found to have HBV surface antigens (HBsAgs) in their serum; however, HBsAgs were not found in any of the Swedish patients. The percentage of serum HBsAgs in Egyptian patients with ABC DLBCL was significantly increased compared with the general Egyptian population (P<0.05). The present study may support a notion that viral agents, including JCV and HBV, may be involved in the tumorigenesis of DLBCL in regions of high infectious disease.

Keywords: gene array; hepatitis B virus; lymphoma and Hodgkin disease; molecular genetics; virus

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