Display options
Cite
Chatzikonstantinou M, Konstantopoulos P, Stergiopoulos S, et al. Calprotectin as a diagnostic tool for inflammatory bowel diseases. Biomed Rep. 2016;5(4):403-407doi: 10.3892/br.2016.751.
Chatzikonstantinou, M., Konstantopoulos, P., Stergiopoulos, S., Kontzoglou, K., Verikokos, C., Perrea, D., & Dimitroulis, D. (2016). Calprotectin as a diagnostic tool for inflammatory bowel diseases. Biomedical reports, 5(4), 403-407. https://doi.org/10.3892/br.2016.751
Chatzikonstantinou, Marianthi, et al. "Calprotectin as a diagnostic tool for inflammatory bowel diseases." Biomedical reports vol. 5,4 (2016): 403-407. doi: https://doi.org/10.3892/br.2016.751
Chatzikonstantinou M, Konstantopoulos P, Stergiopoulos S, Kontzoglou K, Verikokos C, Perrea D, Dimitroulis D. Calprotectin as a diagnostic tool for inflammatory bowel diseases. Biomed Rep. 2016 Oct;5(4):403-407. doi: 10.3892/br.2016.751. Epub 2016 Sep 07. PMID: 27699005; PMCID: PMC5038578.
Copy Download .nbib Format: NLM
Share it on

Biomed Rep. 2016 Oct;5(4):403-407. doi: 10.3892/br.2016.751. Epub 2016 Sep 07.

Calprotectin as a diagnostic tool for inflammatory bowel diseases.

Biomedical reports

Marianthi Chatzikonstantinou, Panagiotis Konstantopoulos, Spyros Stergiopoulos, Konstantinos Kontzoglou, Christos Verikokos, Despina Perrea, Dimitris Dimitroulis

Affiliations

  1. Laboratory of Experimental Surgery and Surgical Research N.S Christeas, National and Kapodistrian University of Athens, Athens 11527, Greece.
  2. Fourth Department of Surgery, Athens University Medical School, Attikon University Hospital, Athens 12462, Greece.
  3. Second Department of Propedeutic Surgery, 'Laiko' General Hospital, National and Kapodistrian University of Athens, Medical School, Athens 11527, Greece.

PMID: 27699005 PMCID: PMC5038578 DOI: 10.3892/br.2016.751

Abstract

Inflammatory bowel diseases (IBD) are chronic intestinal disorders caused by a number of factors, including external influences, intestinal microbiota and genetics. The two major clinically defined types of IBD are Crohn's disease and ulcerative colitis, each of which is characterized by relapses in the clinical course, thus patients must be under constant observation via regular endoscopies. As endoscopy, which has been used for direct evaluation and diagnosis of IBD, requires uncomfortable and expensive bowel preparation, a non-invasive test was required to reduce the number of patients undergoing unnecessary endoscopy. Calprotectin is a protein occurring in the cytosol of inflammatory cells and is released by the activation of leukocytes. As it is elevated and stable in the faeces of patients with IBD and can be reliably detected in faecal samples of <5 g, it may serve as an inexpensive, non-invasive diagnostic method for IBD. This is explored in the following review.

Keywords: calprotectin; diagnostic marker; inflammatory bowel disease

References

  1. Scand J Gastroenterol. 1996 Apr;31(4):339-44 - PubMed
  2. Lancet. 1990 Sep 29;336(8718):763-5 - PubMed
  3. Gastroenterology. 1990 Apr;98(4):811-8 - PubMed
  4. Scand J Gastroenterol. 1992 Sep;27(9):793-8 - PubMed
  5. J Leukoc Biol. 1995 Dec;58(6):650-8 - PubMed
  6. Cell. 1993 Oct 22;75(2):263-74 - PubMed
  7. Scand J Gastroenterol. 1999 Jan;34(1):50-4 - PubMed
  8. Gastroenterology. 2000 Jul;119(1):15-22 - PubMed
  9. QJM. 2002 Sep;95(9):557-8 - PubMed
  10. Cell. 1993 Oct 22;75(2):253-61 - PubMed
  11. Am J Gastroenterol. 2007 Apr;102(4):803-13 - PubMed
  12. J Pediatr Gastroenterol Nutr. 2001 Feb;32(2):171-7 - PubMed
  13. J Infect Dis. 1991 Jan;163(1):187-92 - PubMed
  14. Gut. 2000 Oct;47(4):506-13 - PubMed
  15. Am J Gastroenterol. 2008 Dec;103(12):3167-82 - PubMed
  16. Scand J Gastroenterol. 1993 Dec;28(12):1073-6 - PubMed
  17. Bull Eur Physiopathol Respir. 1980;16 Suppl:273-82 - PubMed
  18. BMJ. 2010 Jul 15;341:c3369 - PubMed
  19. Am J Gastroenterol. 2004 Sep;99(9):1749-55 - PubMed
  20. Annu Rev Immunol. 2009;27:363-91 - PubMed
  21. Am J Gastroenterol. 2000 Oct;95(10):2831-7 - PubMed
  22. Lancet. 1999 May 1;353(9163):1496-7 - PubMed
  23. Gut. 1994 Feb;35(2):231-5 - PubMed
  24. Gut. 1991 Feb;32(2):174-8 - PubMed
  25. Dig Liver Dis. 2003 Sep;35(9):642-7 - PubMed
  26. Cell. 1993 Oct 22;75(2):274-82 - PubMed
  27. Gut. 1999 Sep;45(3):362-6 - PubMed
  28. J Pediatr Gastroenterol Nutr. 2001 Jul;33(1):14-22 - PubMed
  29. Gut. 2005 Mar;54(3):364-8 - PubMed
  30. Gastroenterology. 1996 Jan;110(1):45-51 - PubMed
  31. Scand J Gastroenterol. 2004 Oct;39(10):1017-20 - PubMed
  32. Digestion. 1997;58(2):176-80 - PubMed
  33. Cell Host Microbe. 2008 Jun 12;3(6):417-27 - PubMed
  34. Gut. 1989 May;30(5):618-22 - PubMed
  35. Mol Pathol. 1997 Jun;50(3):113-23 - PubMed
  36. Gut. 1989 Sep;30(9):1236-40 - PubMed
  37. Aliment Pharmacol Ther. 2002 Jul;16 Suppl 4:29-33 - PubMed
  38. Am J Gastroenterol. 2003 Mar;98 (3):578-85 - PubMed
  39. Annu Rev Immunol. 2010;28:573-621 - PubMed
  40. World J Gastroenterol. 2006 Jun 21;12(23):3668-72 - PubMed
  41. Scand J Gastroenterol. 2008 Mar;43(3):356-62 - PubMed
  42. Am J Gastroenterol. 1994 Aug;89(8 Suppl):S53-65 - PubMed
  43. Gut. 2003 Mar;52(3):390-2 - PubMed

Publication Types