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Baumgaertel J, Haussmann R, Gruschwitz A, et al. Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease. Aging Dis. 2016;7(5):553-560doi: 10.14336/AD.2016.0305.
Baumgaertel, J., Haussmann, R., Gruschwitz, A., Werner, A., Osterrath, A., Lange, J., Donix, K. L., Linn, J., & Donix, M. (2016). Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease. Aging and disease, 7(5), 553-560. https://doi.org/10.14336/AD.2016.0305
Baumgaertel, Johanna, et al. "Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease." Aging and disease vol. 7,5 (2016): 553-560. doi: https://doi.org/10.14336/AD.2016.0305
Baumgaertel J, Haussmann R, Gruschwitz A, Werner A, Osterrath A, Lange J, Donix KL, Linn J, Donix M. Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease. Aging Dis. 2016 Oct 01;7(5):553-560. doi: 10.14336/AD.2016.0305. eCollection 2016 Oct. PMID: 27699079; PMCID: PMC5036951.
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Aging Dis. 2016 Oct 01;7(5):553-560. doi: 10.14336/AD.2016.0305. eCollection 2016 Oct.

Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer's Disease.

Aging and disease

Johanna Baumgaertel, Robert Haussmann, Antonia Gruschwitz, Annett Werner, Antje Osterrath, Jan Lange, Katharina L Donix, Jennifer Linn, Markus Donix

Affiliations

  1. 1Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
  2. 3Department of Neuroradiology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
  3. 1Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; 2DZNE, German Center for Neurodegenerative Diseases, Dresden, Germany.

PMID: 27699079 PMCID: PMC5036951 DOI: 10.14336/AD.2016.0305

Abstract

Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for cognitive reserve, would influence hippocampal structure in Alzheimer's disease patients, and whether apolipoprotein Eε4 (APOE4) carrier status and a first-degree family history of the disease would change a possible association. Fifty-eight Alzheimer's disease patients underwent 3T magnetic resonance imaging. We applied a cortical unfolding approach to investigate individual subregions of the medial temporal lobe. Among patients homozygous for the APOE4 genotype or carrying both APOE4 and family history risks, lower education was associated with a thinner cortex in multiple medial temporal regions, including the hippocampus. Our data suggest that the years of formal education and genetic risks interact in their influence on hippocampal structure in Alzheimer's disease patients.

Keywords: apolipoprotein E; cognitive reserve; education; hippocampus

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