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Qian L, Yuanshao L, Wensi H, et al. Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke. Aging Dis. 2016;7(5):614-622doi: 10.14336/AD.2016.0207.
Qian, L., Yuanshao, L., Wensi, H., Yulei, Z., Xiaoli, C., Brian, W., Wanli, Z., Zhengyi, C., Jie, X., Wenhui, Z., Tieer, Y., Hong, W., Jincai, H., Kunlin, J., & Bei, S. (2016). Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke. Aging and disease, 7(5), 614-622. https://doi.org/10.14336/AD.2016.0207
Qian, Li, et al. "Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke." Aging and disease vol. 7,5 (2016): 614-622. doi: https://doi.org/10.14336/AD.2016.0207
Qian L, Yuanshao L, Wensi H, Yulei Z, Xiaoli C, Brian W, Wanli Z, Zhengyi C, Jie X, Wenhui Z, Tieer Y, Hong W, Jincai H, Kunlin J, Bei S. Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke. Aging Dis. 2016 Oct 01;7(5):614-622. doi: 10.14336/AD.2016.0207. eCollection 2016 Oct. PMID: 27699084; PMCID: PMC5036956.
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Aging Dis. 2016 Oct 01;7(5):614-622. doi: 10.14336/AD.2016.0207. eCollection 2016 Oct.

Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke.

Aging and disease

Li Qian, Lin Yuanshao, Huang Wensi, Zhou Yulei, Chen Xiaoli, Wang Brian, Zhang Wanli, Cai Zhengyi, Xue Jie, Zhang Wenhui, Yu Tieer, Wang Hong, He Jincai, Jin Kunlin, Shao Bei

Affiliations

  1. 1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research.
  2. 3Institute for Healthy Aging, Center for Neuroscience Discovery, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.
  3. 2Department of Clinical Laboratory Medicine, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 35000, China.
  4. 1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,; 3Institute for Healthy Aging, Center for Neuroscience Discovery, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA.

PMID: 27699084 PMCID: PMC5036956 DOI: 10.14336/AD.2016.0207

Abstract

Interleukin-33 (IL-33), a newly recognized IL-1 family member, is expressed in various tissues and cells, and involved in pathogenesis of many human diseases. For example, IL-33 plays a protective role in cardiovascular diseases. However, the role of IL-33 in acute ischemic stroke (AIS) remains unclear. This study aims to investigate whether IL-33 level in AIS patient serum can be used as a potential diagnostic and prognostic marker. The study included two hundred and six patients with first-ever ischemic stroke, who were admitted within 72 hours after stroke onset. The serum level of IL-33 was measured with ELISA and the severity of AIS patients on admission was evaluated based on the National Institutes of Health Stroke Scale (NIHSS) score. The functional outcome at 3 months was determined using the Barthel index (BI). We found that serum IL-33 was significantly higher (

Keywords: acute ischemic stroke; biomarker; diagnosis; interleukin-33; outcome

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