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Lin CJ, Li FC, Lee YY, et al. Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound. Biomed Opt Express. 2016;7(9):3574-3584doi: 10.1364/BOE.7.003574.
Lin, C. J., Li, F. C., Lee, Y. Y., Tseng, T. Y., Chen, W. L., Hovhannisyan, V., Kang, N., Horton, N. G., Chiang, S. J., Xu, C., Lee, H. S., & Dong, C. Y. (2016). Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound. Biomedical optics express, 7(9), 3574-3584. https://doi.org/10.1364/BOE.7.003574
Lin, Chih-Ju, et al. "Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound." Biomedical optics express vol. 7,9 (2016): 3574-3584. doi: https://doi.org/10.1364/BOE.7.003574
Lin CJ, Li FC, Lee YY, Tseng TY, Chen WL, Hovhannisyan V, Kang N, Horton NG, Chiang SJ, Xu C, Lee HS, Dong CY. Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound. Biomed Opt Express. 2016 Aug 19;7(9):3574-3584. doi: 10.1364/BOE.7.003574. eCollection 2016 Sep 01. PMID: 27699121; PMCID: PMC5030033.
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Biomed Opt Express. 2016 Aug 19;7(9):3574-3584. doi: 10.1364/BOE.7.003574. eCollection 2016 Sep 01.

Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound.

Biomedical optics express

Chih-Ju Lin, Feng-Chieh Li, Yu-Yang Lee, Te-Yu Tseng, Wei-Liang Chen, Vladimir Hovhannisyan, Ning Kang, Nicholas G Horton, Shu-Jen Chiang, Chris Xu, Hsuan-Shu Lee, Chen-Yuan Dong

Affiliations

  1. Department of Physics, National Taiwan University, Taipei 106, Taiwan.
  2. School of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14853, USA.
  3. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan; Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan; [email protected].
  4. Department of Physics, National Taiwan University, Taipei 106, Taiwan; Center for Optoelectronic Biomedicine, National Taiwan University, Taipei 106, Taiwan; Center for Quantum Science and Engineering, National Taiwan University, Taipei 106, Taiwan; [email protected].

PMID: 27699121 PMCID: PMC5030033 DOI: 10.1364/BOE.7.003574

Abstract

Hepatobiliary metabolism is one of the major functions of the liver. However, little is known of the relationship between the physiological location of the hepatocytes and their metabolic potential. By the combination of time-lapse multiphoton microscopy and first order kinetic constant image analysis, the hepatocellular metabolic rate of the model compound 6-carboxyfluorescein diacetate (6-CFDA) is quantified at the single cell level. We found that the mouse liver can be divided into three zones, each with distinct metabolic rate constants. The sinusoidal uptake coefficients k

Keywords: (190.0190) Nonlinear optics; (190.4180) Multiphoton processes

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