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Endres D, Tebartz van Elst L, Feige B, et al. On the Effect of Sex on Prefrontal and Cerebellar Neurometabolites in Healthy Adults: An MRS Study. Front Hum Neurosci. 2016;10:367doi: 10.3389/fnhum.2016.00367.
Endres, D., Tebartz van Elst, L., Feige, B., Backenecker, S., Nickel, K., Bubl, A., Lange, T., Mader, I., Maier, S., & Perlov, E. (2016). On the Effect of Sex on Prefrontal and Cerebellar Neurometabolites in Healthy Adults: An MRS Study. Frontiers in human neuroscience, 10367. https://doi.org/10.3389/fnhum.2016.00367
Endres, Dominique, et al. "On the Effect of Sex on Prefrontal and Cerebellar Neurometabolites in Healthy Adults: An MRS Study." Frontiers in human neuroscience vol. 10 (2016): 367. doi: https://doi.org/10.3389/fnhum.2016.00367
Endres D, Tebartz van Elst L, Feige B, Backenecker S, Nickel K, Bubl A, Lange T, Mader I, Maier S, Perlov E. On the Effect of Sex on Prefrontal and Cerebellar Neurometabolites in Healthy Adults: An MRS Study. Front Hum Neurosci. 2016 Aug 02;10:367. doi: 10.3389/fnhum.2016.00367. eCollection 2016. PMID: 27531975; PMCID: PMC4969301.
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Front Hum Neurosci. 2016 Aug 02;10:367. doi: 10.3389/fnhum.2016.00367. eCollection 2016.

On the Effect of Sex on Prefrontal and Cerebellar Neurometabolites in Healthy Adults: An MRS Study.

Frontiers in human neuroscience

Dominique Endres, Ludger Tebartz van Elst, Bernd Feige, Stephan Backenecker, Kathrin Nickel, Anna Bubl, Thomas Lange, Irina Mader, Simon Maier, Evgeniy Perlov

Affiliations

  1. Section for Experimental Neuropsychiatry, Department for Psychiatry and Psychotherapy, University Medical Center Freiburg Freiburg, Germany.
  2. Department for Psychiatry and Psychotherapy, Saarland University Medical Center Homburg, Germany.
  3. Department for Radiology, Medical Physics, University Medical Center Freiburg Freiburg, Germany.
  4. Department of Neuroradiology, University Medical Center Freiburg Freiburg, Germany.

PMID: 27531975 PMCID: PMC4969301 DOI: 10.3389/fnhum.2016.00367

Abstract

In neuropsychiatric research, the aspects of sex have received increasing attention over the past decade. With regard to the neurometabolic differences in the prefrontal cortex and the cerebellum of both men and women, we performed a magnetic resonance spectroscopic (MRS) study of a large group of healthy subjects. For neurometabolic measurements, we used single-voxel proton MRS. The voxels of interest (VOI) were placed in the pregenual anterior cingulate cortex (pACC) and the left cerebellar hemisphere. Absolute quantification of creatine (Cre), total choline (t-Cho), glutamate and glutamine (Glx), N-acetylaspartate, and myo-inositol (mI) was performed. Thirty-three automatically matched ACCs and 31 cerebellar male-female pairs were statistically analyzed. We found no significant neurometabolic differences in the pACC region (Wilks' lambda: p = 0.657). In the left cerebellar region, we detected significant variations between the male and female groups (p = 0.001). Specifically, we detected significantly higher Cre (p = 0.005) and t-Cho (p = 0.000) levels in men. Additionally, males tended to have higher Glx and mI concentrations. This is the first study to report neurometabolic sex differences in the cerebellum. The effects of sexual hormones might have influenced our findings. Our data indicates the importance of adjusting for the confounding effects of sex in MRS studies.

Keywords: MR spectroscopy; cerebellum; choline; creatine; sex

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