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Heliyon. 2016 Sep 19;2(9):e00158. doi: 10.1016/j.heliyon.2016.e00158. eCollection 2016 Sep.

Identification of Leukotoxin and other vaccine candidate proteins in a .

Heliyon

Paula Tucci, Verónica Estevez, Lorena Becco, Florencia Cabrera-Cabrera, Germán Grotiuz, Eduardo Reolon, Mónica Marín

Affiliations

  1. Biotechnology Division, Laboratorios Celsius, S.A. Avenida Italia 6201, Montevideo, Uruguay; Biochemistry-Molecular Biology Section, Faculty of Sciences, Universidad de la República, Iguá 4225, Montevideo, Uruguay.
  2. Biotechnology Division, Laboratorios Celsius, S.A. Avenida Italia 6201, Montevideo, Uruguay.
  3. Biochemistry-Molecular Biology Section, Faculty of Sciences, Universidad de la República, Iguá 4225, Montevideo, Uruguay.
  4. Virbac Uruguay, S.A. Avda. Millán 4175, Montevideo, Uruguay.

PMID: 27699279 PMCID: PMC5035357 DOI: 10.1016/j.heliyon.2016.e00158

Abstract

Bovine Respiratory Disease is the most costly disease that affects beef and dairy cattle industry. Its etiology is multifactorial, arising from predisposing environmental stress conditions as well as the action of several different respiratory pathogens. This situation has hindered the development of effective control strategies. Although different type of vaccines are available, many currently marketed vaccines are based on inactivated cultures of the main viral and bacterial agents involved in this pathology. The molecular composition of commercial veterinary vaccines is a critical issue. The present work aims to define at the proteomic level the most relevant valence of a line of commercial respiratory vaccines widely used in Central and South America. Since

Keywords: Biological Sciences; Immunology; Microbiology

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