Display options
Cite
Kishikawa T, Otsuka M, Yoshikawa T, et al. Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1. Nat Commun. 2016;7:13006doi: 10.1038/ncomms13006.
Kishikawa, T., Otsuka, M., Yoshikawa, T., Ohno, M., Ijichi, H., & Koike, K. (2016). Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1. Nature communications, 713006. https://doi.org/10.1038/ncomms13006
Kishikawa, Takahiro, et al. "Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1." Nature communications vol. 7 (2016): 13006. doi: https://doi.org/10.1038/ncomms13006
Kishikawa T, Otsuka M, Yoshikawa T, Ohno M, Ijichi H, Koike K. Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1. Nat Commun. 2016 Sep 26;7:13006. doi: 10.1038/ncomms13006. PMID: 27667193; PMCID: PMC5052683.
Copy Download .nbib Format: NLM
Share it on

Nat Commun. 2016 Sep 26;7:13006. doi: 10.1038/ncomms13006.

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1.

Nature communications

Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi, Kazuhiko Koike

Affiliations

  1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
  2. Japan Science and Technology Agency, PRESTO, Kawaguchi, Saitama 332-0012, Japan.

PMID: 27667193 PMCID: PMC5052683 DOI: 10.1038/ncomms13006

Abstract

Highly repetitive tandem arrays at the centromeric and pericentromeric regions in chromosomes, previously considered silent, are actively transcribed, particularly in cancer. This aberrant expression occurs even in K-ras-mutated pancreatic intraepithelial neoplasia (PanIN) tissues, which are precancerous lesions. To examine the biological roles of the satellite RNAs in carcinogenesis, we construct mouse PanIN-derived cells expressing major satellite (MajSAT) RNA and show increased malignant properties. We find an increase in frequency of chromosomal instability and point mutations in both genomic and mitochondrial DNA. We identify Y-box binding protein 1 (YBX1) as a protein that binds to MajSAT RNA. MajSAT RNA inhibits the nuclear translocation of YBX1 under stress conditions, thus reducing its DNA-damage repair function. The forced expression of YBX1 significantly decreases the aberrant phenotypes. These findings indicate that during the early stage of cancer development, satellite transcripts may act as 'intrinsic mutagens' by inducing YBX1 dysfunction, which may be crucial in oncogenic processes.

References

  1. Sci Rep. 2012;2:637 - PubMed
  2. Curr Biol. 2003 Jul 15;13(14):1192-200 - PubMed
  3. Genes Dev. 2001 Dec 15;15(24):3243-8 - PubMed
  4. Genes Dev. 2013 Nov 15;27(22):2427-32 - PubMed
  5. Cell. 2013 Mar 14;152(6):1298-307 - PubMed
  6. Genesis. 2002 Feb;32(2):73-5 - PubMed
  7. Nat Genet. 2011 Mar;43(3):220-7 - PubMed
  8. Mol Cancer. 2002 Dec 09;1:9 - PubMed
  9. Wiley Interdiscip Rev RNA. 2014 Jan-Feb;5(1):95-110 - PubMed
  10. Mol Cancer. 2011 Nov 10;10 :138 - PubMed
  11. J Cell Biol. 2014 Nov 10;207(3):335-49 - PubMed
  12. N Engl J Med. 2015 Nov 12;373(20):1895-8 - PubMed
  13. Cancer Res. 1999 Jan 15;59(2):342-6 - PubMed
  14. FEBS Lett. 1997 Nov 17;417(3):390-4 - PubMed
  15. Nature. 2011 Sep 07;477(7363):179-84 - PubMed
  16. Cell. 2015 May 7;161(4):790-802 - PubMed
  17. Genome Res. 2012 Mar;22(3):568-76 - PubMed
  18. Nat Med. 2006 Jan;12(1):128-32 - PubMed
  19. Nature. 2012 Oct 25;490(7421):547-51 - PubMed
  20. DNA Repair (Amst). 2009 Jun 4;8(6):704-19 - PubMed
  21. Nucleic Acids Res. 2008 Feb;36(2):423-34 - PubMed
  22. Genes Dev. 2006 Nov 15;20(22):3147-60 - PubMed
  23. Nat Genet. 2002 Sep;32(1):128-34 - PubMed
  24. Biochemistry (Mosc). 2011 Dec;76(13):1402-33 - PubMed
  25. Exp Cell Res. 2005 Nov 1;310(2):344-56 - PubMed
  26. Nature. 2012 Nov 15;491(7424):399-405 - PubMed
  27. Oncogene. 2006 Aug 7;25(34):4647-62 - PubMed
  28. Int J Biochem Cell Biol. 2006;38(8):1300-13 - PubMed
  29. J Cell Biol. 2004 Jan 5;164(1):25-33 - PubMed
  30. J Clin Invest. 2011 Oct;121(10):4106-17 - PubMed
  31. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15154-9 - PubMed
  32. Clin Cancer Res. 2000 Aug;6(8):2969-72 - PubMed
  33. Nucleic Acids Res. 2004 Jan 12;32(1):316-27 - PubMed
  34. J Biol Chem. 2007 Sep 28;282(39):28474-84 - PubMed
  35. Environ Mol Mutagen. 2014 Mar;55(2):122-33 - PubMed
  36. Curr Mol Med. 2007 Feb;7(1):121-31 - PubMed
  37. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15148-53 - PubMed
  38. Neoplasia. 2005 Jan;7(1):17-23 - PubMed
  39. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E89-98 - PubMed
  40. PLoS One. 2013 Sep 02;8(9):e71969 - PubMed
  41. J Biol Chem. 2003 Sep 12;278(37):35516-23 - PubMed
  42. Science. 2008 Sep 26;321(5897):1801-6 - PubMed
  43. Nat Struct Mol Biol. 2012 Oct;19(10 ):1023-30 - PubMed
  44. Science. 2011 Feb 4;331(6017):593-6 - PubMed
  45. Chromosome Res. 2015 Sep;23(3):463-77 - PubMed
  46. Int J Dev Biol. 2009;53(2-3):259-68 - PubMed
  47. Biomed Res Int. 2013;2013:612369 - PubMed
  48. J Biol Chem. 2005 Mar 4;280(9):7702-11 - PubMed
  49. Dev Cell. 2010 Oct 19;19(4):625-38 - PubMed
  50. Nature. 2015 Feb 26;518(7540):495-501 - PubMed
  51. Fly (Austin). 2012 Apr-Jun;6(2):80-92 - PubMed
  52. J Genet Genomics. 2009 Mar;36(3):125-31 - PubMed
  53. Annu Rev Biochem. 2012;81:145-66 - PubMed
  54. Nat Rev Cancer. 2002 Dec;2(12):897-909 - PubMed
  55. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8709-14 - PubMed
  56. Nucleic Acids Res. 2009 Aug;37(15):5071-80 - PubMed
  57. J Mol Recognit. 2012 Apr;25(4):224-33 - PubMed
  58. Mol Cell. 2013 Dec 12;52(5):746-57 - PubMed
  59. Cancer Prev Res (Phila). 2011 May;4(5):638-54 - PubMed
  60. Gastroenterology. 2016 Jan;150(1):48-63 - PubMed
  61. Mutat Res. 2003 May 15;526(1-2):1-7 - PubMed
  62. Bioinformatics. 2009 Jul 15;25(14):1754-60 - PubMed
  63. Environ Mol Mutagen. 2001;38(2-3):180-90 - PubMed
  64. Chromosoma. 2014 Aug;123(4):313-25 - PubMed
  65. Hum Genet. 1994 Apr;93(4):383-8 - PubMed
  66. Mech Ageing Dev. 2013 Oct;134(10):460-6 - PubMed
  67. Epigenetics. 2012 Aug;7(8):903-13 - PubMed
  68. Genes Cells. 2014 Jun;19(6):528-38 - PubMed
  69. Clin Cancer Res. 2011 Nov 15;17(22):6973-84 - PubMed

Publication Types