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Ahmed MB, Patel K, Fonarow GC, et al. Higher risk for incident heart failure and cardiovascular mortality among community-dwelling octogenarians without pneumococcal vaccination. ESC Heart Fail. 2015;3(1):11-17doi: 10.1002/ehf2.12056.
Ahmed, M. B., Patel, K., Fonarow, G. C., Morgan, C. J., Butler, J., Bittner, V., Kulczycki, A., Kheirbek, R. E., Aronow, W. S., Fletcher, R. D., Brown, C. J., & Ahmed, A. (2016). Higher risk for incident heart failure and cardiovascular mortality among community-dwelling octogenarians without pneumococcal vaccination. ESC heart failure, 3(1), 11-17. https://doi.org/10.1002/ehf2.12056
Ahmed, Momanna B, et al. "Higher risk for incident heart failure and cardiovascular mortality among community-dwelling octogenarians without pneumococcal vaccination." ESC heart failure vol. 3,1 (2016): 11-17. doi: https://doi.org/10.1002/ehf2.12056
Ahmed MB, Patel K, Fonarow GC, Morgan CJ, Butler J, Bittner V, Kulczycki A, Kheirbek RE, Aronow WS, Fletcher RD, Brown CJ, Ahmed A. Higher risk for incident heart failure and cardiovascular mortality among community-dwelling octogenarians without pneumococcal vaccination. ESC Heart Fail. 2016 Mar;3(1):11-17. doi: 10.1002/ehf2.12056. Epub 2015 Sep 21. PMID: 27668089; PMCID: PMC5019269.
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ESC Heart Fail. 2016 Mar;3(1):11-17. doi: 10.1002/ehf2.12056. Epub 2015 Sep 21.

Higher risk for incident heart failure and cardiovascular mortality among community-dwelling octogenarians without pneumococcal vaccination.

ESC heart failure

Momanna B Ahmed, Kanan Patel, Gregg C Fonarow, Charity J Morgan, Javed Butler, Vera Bittner, Andrzej Kulczycki, Raya E Kheirbek, Wilbert S Aronow, Ross D Fletcher, Cynthia J Brown, Ali Ahmed

Affiliations

  1. University of Alabama at Birmingham Birmingham AL USA.
  2. University of California San Francisco CA USA.
  3. University of California Los Angeles CA USA.
  4. Stony Brook University Stony Brook NY USA.
  5. Veterans Affairs Medical Center Washington DC USA.
  6. New York Medical College Valhalla NY USA.
  7. University of Alabama at BirminghamBirminghamALUSA; Veterans Affairs Medical CenterBirminghamALUSA.
  8. University of Alabama at BirminghamBirminghamALUSA; Veterans Affairs Medical CenterWashingtonDCUSA.

PMID: 27668089 PMCID: PMC5019269 DOI: 10.1002/ehf2.12056

Abstract

AIMS: Octogenarians have the highest incidence of heart failure (HF) that is not fully explained by traditional risk factors. We explored whether lack of pneumococcal vaccination is associated with higher risk of incident HF among octogenarians.

METHODS AND RESULTS: In the Cardiovascular Health Study (CHS), 5290 community-dwelling adults, ≥65 years of age, were free of baseline HF and had data on pneumococcal vaccination. Of these, 851 were octogenarians, of whom, 593 did not receive pneumococcal vaccination. Multivariable-adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for associations of lack of pneumococcal vaccination with incident HF and other outcomes during 13 years of follow-up were estimated using Cox regression models, adjusting for demographics and other HF risk factors including influenza vaccination. Octogenarians had a mean (±SD) age of 83 (±3) years; 52% were women and 17% African American. Overall, 258 participants developed HF and 662 died. Lack of pneumococcal vaccination was associated with higher relative risk of incident HF (aHR, 1.37; 95% CI, 1.01-1.85;

CONCLUSIONS: Among community-dwelling octogenarians, lack of pneumococcal vaccination was associated with a significantly higher independent risk of incident HF and mortality, and trend for higher pneumonia hospitalization.

Keywords: Heart failure; Mortality; Octogenarians; Pneumococcal vaccination

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