Int J Ophthalmol. 2016 Jul 18;9(7):1038-45. doi: 10.18240/ijo.2016.07.17. eCollection 2016.
Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis.
International journal of ophthalmology
Ye-Lei Tang, Ya-Lan Cheng, Yu-Ping Ren, Xiao-Ning Yu, Xing-Chao Shentu
Affiliations
Affiliations
- Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China.
- Eye Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China.
PMID: 27500114
PMCID: PMC4951660 DOI: 10.18240/ijo.2016.07.17
Abstract
AIM: To explore the relationship between metabolic risk factors and dry eye syndrome (DES).
METHODS: Retrieved studies on the association of metabolic syndrome risk factors (hypertension, hyperglycemia, obesity, and hyperlipidemia) and DES were collected from PubMed, Web of Science, and the Cochrane Library in December 2015. Odds ratio (OR) with 95% confidence interval (CI) were pooled to evaluate the final relationship. Subgroup analyses were conducted according to diagnostic criteria of DES.
RESULTS: Nine cross-sectional studies and three case-control studies were included in this Meta-analysis. The pooled results showed that people with hypertension, hyperglycemia, and hyperlipidemia had a higher risk of suffering from DES (P<0.05), especially the typical DES symptoms. On the other hand, obesity did not increase the risk of DES.
CONCLUSION: The present Meta-analysis suggests that all metabolic risk factors except obesity were risk factors for DES.
Keywords: Meta-analysis; dry eye syndrome; hyperglycemia; hyperlipidemia; hypertension; obesity
References
- Br J Ophthalmol. 2014 Dec;98 (12 ):1712-7 - PubMed
- Br J Ophthalmol. 2014 Mar;98(3):418-20 - PubMed
- Optom Vis Sci. 2015 Sep;92(9):e199-205 - PubMed
- Clin Exp Ophthalmol. 2003 Jun;31(3):229-32 - PubMed
- Clin Exp Optom. 2015 Jan;98(1):45-53 - PubMed
- Int J Surg. 2010;8(5):336-41 - PubMed
- JAMA Ophthalmol. 2015 Dec;133(12):1481-2 - PubMed
- Eye (Lond). 2009 Mar;23(3):688-93 - PubMed
- Ocul Surf. 2007 Apr;5(2):163-78 - PubMed
- Am J Ophthalmol. 2012 Aug;154(2):340-346.e2 - PubMed
- Blood Press. 2016;25(1):11-20 - PubMed
- BMJ. 2003 Sep 6;327(7414):557-60 - PubMed
- Arch Ophthalmol. 2009 Jun;127(6):763-8 - PubMed
- Ophthalmologe. 1995 Feb;92(1):12-6 - PubMed
- Arch Ophthalmol. 2000 Sep;118(9):1264-8 - PubMed
- CLAO J. 1995 Oct;21(4):221-32 - PubMed
- Am J Ophthalmol. 2014 Dec;158(6):1205-1214.e7 - PubMed
- Ophthalmology. 2011 Dec;118(12):2361-7 - PubMed
- Acta Ophthalmol. 2014 Sep;92(6):e429-36 - PubMed
- Contemp Clin Trials. 2007 Feb;28(2):105-14 - PubMed
- Ophthalmology. 2009 Oct;116(10):1872-9 - PubMed
- BMJ. 1997 Sep 13;315(7109):629-34 - PubMed
- Ophthalmic Epidemiol. 2009 Jan-Feb;16(1):15-21 - PubMed
- Am J Ophthalmol. 2013 Oct;156(4):759-66 - PubMed
- Curr Eye Res. 2011 Jan;36(1):1-7 - PubMed
- Ocul Surf. 2007 Apr;5(2):75-92 - PubMed
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