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Mikami S, Ota I, Masui T, et al. Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. Int J Oncol. 2016;49(4):1553-1560doi: 10.3892/ijo.2016.3664.
Mikami, S., Ota, I., Masui, T., Itaya-Hironaka, A., Shobatake, R., Okamoto, H., Takasawa, S., & Kitahara, T. (2016). Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. International journal of oncology, 49(4), 1553-1560. https://doi.org/10.3892/ijo.2016.3664
Mikami, Shinji, et al. "Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells." International journal of oncology vol. 49,4 (2016): 1553-1560. doi: https://doi.org/10.3892/ijo.2016.3664
Mikami S, Ota I, Masui T, Itaya-Hironaka A, Shobatake R, Okamoto H, Takasawa S, Kitahara T. Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. Int J Oncol. 2016 Oct;49(4):1553-1560. doi: 10.3892/ijo.2016.3664. Epub 2016 Aug 19. PMID: 27633858.
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Int J Oncol. 2016 Oct;49(4):1553-1560. doi: 10.3892/ijo.2016.3664. Epub 2016 Aug 19.

Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.

International journal of oncology

Shinji Mikami, Ichiro Ota, Takashi Masui, Asako Itaya-Hironaka, Ryogo Shobatake, Hideyuki Okamoto, Shin Takasawa, Tadashi Kitahara

Affiliations

  1. Department of Otolaryngology?Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634?8522, Japan.
  2. Department of Biochemistry, Nara Medical University, Kashihara, Nara 634?8522, Japan.
  3. Department of Otolaryngology, Nara City Hospital, Nara 630?8305, Japan.

PMID: 27633858 DOI: 10.3892/ijo.2016.3664

Abstract

Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.

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