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Smolyakov G, Thiebot B, Campillo C, et al. Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential. ACS Appl Mater Interfaces. 2016;8(41):27426-27431doi: 10.1021/acsami.6b07698.
Smolyakov, G., Thiebot, B., Campillo, C., Labdi, S., Severac, C., Pelta, J., & Dague, �. �. (2016). Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential. ACS applied materials & interfaces, 8(41), 27426-27431. https://doi.org/10.1021/acsami.6b07698
Smolyakov, Georges, et al. "Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential." ACS applied materials & interfaces vol. 8,41 (2016): 27426-27431. doi: https://doi.org/10.1021/acsami.6b07698
Smolyakov G, Thiebot B, Campillo C, Labdi S, Severac C, Pelta J, Dague É. Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential. ACS Appl Mater Interfaces. 2016 Oct 19;8(41):27426-27431. doi: 10.1021/acsami.6b07698. Epub 2016 Oct 10. PMID: 27701866.
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ACS Appl Mater Interfaces. 2016 Oct 19;8(41):27426-27431. doi: 10.1021/acsami.6b07698. Epub 2016 Oct 10.

Elasticity, Adhesion, and Tether Extrusion on Breast Cancer Cells Provide a Signature of Their Invasive Potential.

ACS applied materials & interfaces

Georges Smolyakov, Bénédicte Thiebot, Clément Campillo, Sid Labdi, Childerick Severac, Juan Pelta, Étienne Dague

Affiliations

  1. ITAV CNRS, Université de Toulouse, CNRS , Toulouse 31062, France.
  2. LAAS-CNRS, Université de Toulouse, CNRS , Toulouse 31400, France.
  3. Laboratoire d'Analyse et Modélisation pour la Biologie et l'Environnement LAMBE-CNRS, Université d'Evry , Evry F-91025, France.

PMID: 27701866 DOI: 10.1021/acsami.6b07698

Abstract

We use single-cell force spectroscopy to compare elasticity, adhesion, and tether extrusion on four breast cancer cell lines with an increasing invasive potential. We perform cell attachment/detachment experiments either on fibronectin or on another cell using an atomic force microscope. Our study on the membrane tether formation from cancer cells show that they are easier to extrude from aggressive invasive cells. Measured elastic modulus values confirm that more invasive cells are softer. Moreover, the adhesion force increases with the invasive potential. Our results provide a mechanical signature of breast cancer cells that correlates with their invasivity.

Keywords: AFM; adhesion; cancer; invasivity; metastasis; nanomechanics; single-cell force spectroscopy; tethers

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