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Ishikawa E, Kosako H, Yasuda T, et al. Protein kinase D regulates positive selection of CD4. Nat Commun. 2016;7:12756doi: 10.1038/ncomms12756.
Ishikawa, E., Kosako, H., Yasuda, T., Ohmuraya, M., Araki, K., Kurosaki, T., Saito, T., & Yamasaki, S. (2016). Protein kinase D regulates positive selection of CD4. Nature communications, 712756. https://doi.org/10.1038/ncomms12756
Ishikawa, Eri, et al. "Protein kinase D regulates positive selection of CD4." Nature communications vol. 7 (2016): 12756. doi: https://doi.org/10.1038/ncomms12756
Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S. Protein kinase D regulates positive selection of CD4. Nat Commun. 2016 Sep 27;7:12756. doi: 10.1038/ncomms12756. PMID: 27670070; PMCID: PMC5052653.
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Nat Commun. 2016 Sep 27;7:12756. doi: 10.1038/ncomms12756.

Protein kinase D regulates positive selection of CD4.

Nature communications

Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito, Sho Yamasaki

Affiliations

  1. Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi Higashiku, Fukuoka 812-8582, Japan.
  2. Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
  3. Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
  4. Institute of Resource Development and Analysis, Kumamoto University, 2-2-1, Honjo, Chuo-ku, Kumamoto 860-0811, Japan.
  5. Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center (iFReC), Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan.
  6. Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
  7. Laboratory for Cell Signaling, WPI Immunology Frontier Research Center (iFReC), Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan.

PMID: 27670070 PMCID: PMC5052653 DOI: 10.1038/ncomms12756

Abstract

Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development. Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for thymocyte positive selection. In T cell-specific PKD-deficient (PKD2/PKD3 double-deficient) mice, the generation of CD4 single positive thymocytes is abrogated. This defect is likely caused by attenuated TCR signalling during positive selection and incomplete CD4 lineage specification in PKD-deficient thymocytes; however, TCR-proximal tyrosine phosphorylation is not affected. PKD is activated in CD4

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