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Paulose R, Chhablani J, Dedhia CJ, et al. Intravitreal ziv-aflibercept for macular edema following retinal vein occlusion. Clin Ophthalmol. 2016;10:1853-1858doi: 10.2147/OPTH.S116343.
Paulose, R., Chhablani, J., Dedhia, C. J., Stewart, M. W., & Mansour, A. M. (2016). Intravitreal ziv-aflibercept for macular edema following retinal vein occlusion. Clinical ophthalmology (Auckland, N.Z.), 101853-1858. https://doi.org/10.2147/OPTH.S116343
Paulose, Remya, et al. "Intravitreal ziv-aflibercept for macular edema following retinal vein occlusion." Clinical ophthalmology (Auckland, N.Z.) vol. 10 (2016): 1853-1858. doi: https://doi.org/10.2147/OPTH.S116343
Paulose R, Chhablani J, Dedhia CJ, Stewart MW, Mansour AM. Intravitreal ziv-aflibercept for macular edema following retinal vein occlusion. Clin Ophthalmol. 2016 Sep 22;10:1853-1858. doi: 10.2147/OPTH.S116343. eCollection 2016. PMID: 27703326; PMCID: PMC5038569.
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Clin Ophthalmol. 2016 Sep 22;10:1853-1858. doi: 10.2147/OPTH.S116343. eCollection 2016.

Intravitreal ziv-aflibercept for macular edema following retinal vein occlusion.

Clinical ophthalmology (Auckland, N.Z.)

Remya Paulose, Jay Chhablani, Chintan J Dedhia, Michael W Stewart, Ahmad M Mansour

Affiliations

  1. Smt. Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, India.
  2. Department of Ophthalmology, Mayo Clinic, Jacksonville, FL, USA.
  3. Department of Ophthalmology, American University of Beirut; Department of Ophthalmology, Rafic Hariri University Hospital, Beirut, Lebanon.

PMID: 27703326 PMCID: PMC5038569 DOI: 10.2147/OPTH.S116343

Abstract

AIM: To report the efficacy of intravitreal ziv-aflibercept injections in eyes with macular edema due to retinal vein occlusions (RVOs).

METHODS: Consecutive patients with persistent or recurrent macular edema (central macula thickness >250 μm) due to RVO were enrolled in this prospective study. Study eyes received intravitreal injections of ziv-aflibercept (1.25 mg/0.05 mL) at baseline. Patients were reassessed monthly for 4 months and given additional injections pro re nata for worsening best-corrected visual acuity (BCVA), intraretinal edema or subretinal fluid seen on spectral domain optical coherence tomography, or central macular thickness (CMT) measurements >250 μm. The primary endpoint was improvement in mean CMT at 4 months. Secondary endpoints included improvement in mean BCVA, and ocular and systemic safety signals.

RESULTS: Nine eyes (five central and four branch RVOs) of nine patients were enrolled. The mean ± standard deviation CMT decreased from 604±199 μm at baseline to 319±115 μm (

CONCLUSION: In this small prospective study, intravitreal ziv-aflibercept significantly improved mean CMT in eyes with persistent or recurrent macular edema due to RVOs. Prospective, randomized trials comparing ziv-aflibercept with standard pharmacotherapy are needed to better define efficacy and safety.

Keywords: cystoid macular edema; retinal vein occlusion; ziv-aflibercept

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