Display options
Cite
Tozaki T, Sato F, Ishimaru M, et al. Sequence variants of . J Equine Sci. 2016;27(3):107-114doi: 10.1294/jes.27.107.
Tozaki, T., Sato, F., Ishimaru, M., Kikuchi, M., Kakoi, H., Hirota, K. I., & Nagata, S. I. (2016). Sequence variants of . Journal of equine science, 27(3), 107-114. https://doi.org/10.1294/jes.27.107
Tozaki, Teruaki, et al. "Sequence variants of ." Journal of equine science vol. 27,3 (2016): 107-114. doi: https://doi.org/10.1294/jes.27.107
Tozaki T, Sato F, Ishimaru M, Kikuchi M, Kakoi H, Hirota KI, Nagata SI. Sequence variants of . J Equine Sci. 2016;27(3):107-114. doi: 10.1294/jes.27.107. Epub 2016 Sep 30. PMID: 27703405; PMCID: PMC5048357.
Copy Download .nbib Format: NLM
Share it on

J Equine Sci. 2016;27(3):107-114. doi: 10.1294/jes.27.107. Epub 2016 Sep 30.

Sequence variants of .

Journal of equine science

Teruaki Tozaki, Fumio Sato, Mutsuki Ishimaru, Mio Kikuchi, Hironaga Kakoi, Kei-Ichi Hirota, Shun-Ichi Nagata

Affiliations

  1. Genetic Analysis Department, Laboratory of Racing Chemistry, Tochigi 320-0851, Japan.
  2. Hidaka Training and Research Center, Japan Racing Association, Hokkaido 057-0171, Japan.

PMID: 27703405 PMCID: PMC5048357 DOI: 10.1294/jes.27.107

Abstract

Ligand-dependent nuclear receptor compressor-like (LCORL) encodes a transcription factor, and its polymorphisms are associated with measures of skeletal frame size and adult height in several species. Recently, the single nucleotide polymorphism (SNP) BIEC2-808543 located upstream of LCORL was identified as a genetic diagnostic marker associated with withers height in Thoroughbreds. In this study, 322 Thoroughbreds-in-training were genotyped for BIEC2-808543 to evaluate the association between genotype and body composition traits, including body weight, withers height, the ratio of body weight to withers height, chest circumference, and cannon circumference. Of these, withers height and cannon circumference were significantly associated with LCORL genotypes throughout almost the entire training period in males and females. Animals with a C/T genotype had higher withers height (maximum differences of 1.8 cm and 2.1 cm in males and females, respectively) and cannon circumstance (maximum differences of 0.65 cm and 0.48 cm in males and females, respectively) compared with animals with a T/T genotype. These results suggested that the regulation of LCORL expression influences the skeletal frame size in Thoroughbreds and thus, indirectly affects the body weight. Although LCORL and BIEC2-808543 would be useful for selective breeding in Thoroughbreds, the production of genetically modified animals and gene doping based on genetic information should be prohibited in order to maintain racing integrity.

Keywords: BIEC2-808543; LCORL; Thoroughbred; cannon circumstance; withers height

References

  1. PLoS One. 2012;7(7):e39929 - PubMed
  2. PLoS Genet. 2009 Apr;5(4):e1000445 - PubMed
  3. BMC Genet. 2011 Dec 14;12:103 - PubMed
  4. Anim Genet. 2001 Dec;32(6):360-4 - PubMed
  5. Hum Genet. 2011 May;129(5):465-72 - PubMed
  6. Drug Metab Pers Ther. 2016 Mar;31(1):3-8 - PubMed
  7. Nature. 2015 Apr 9;520(7546):186-91 - PubMed
  8. Biol Sport. 2014 Dec;31(4):251-9 - PubMed
  9. Equine Vet J. 2006 Nov;38(7):616-21 - PubMed
  10. Horm Res. 2009 Apr;71 Suppl 2:5-13 - PubMed
  11. Microbiol Spectr. 2015 Aug;3(4):null - PubMed
  12. PLoS One. 2013;8(2):e56497 - PubMed
  13. Curr Opin Pharmacol. 2015 Oct;24:59-67 - PubMed
  14. PLoS One. 2012;7(5):e37282 - PubMed
  15. Equine Vet J. 2013 Sep;45(5):552-7 - PubMed
  16. Cell. 2014 Jun 5;157(6):1262-78 - PubMed
  17. Vet J. 2002 Jan;163(1):19-29 - PubMed
  18. Biol Lett. 2011 Apr 23;7(2):316-20 - PubMed
  19. J Vet Med Sci. 2011 Dec;73(12):1617-24 - PubMed
  20. Anim Sci J. 2016 Feb;87(2):159-67 - PubMed
  21. Equine Vet J. 2006 Nov;38(7):597-603 - PubMed

Publication Types