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Suwanjang W, Prachayasittikul S, Prachayasittikul V. Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose. PeerJ. 2016;4:e2389doi: 10.7717/peerj.2389.
Suwanjang, W., Prachayasittikul, S., & Prachayasittikul, V. (2016). Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose. PeerJ, 4e2389. https://doi.org/10.7717/peerj.2389
Suwanjang, Wilasinee, et al. "Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose." PeerJ vol. 4 (2016): e2389. doi: https://doi.org/10.7717/peerj.2389
Suwanjang W, Prachayasittikul S, Prachayasittikul V. Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose. PeerJ. 2016 Aug 31;4:e2389. doi: 10.7717/peerj.2389. eCollection 2016. PMID: 27635352; PMCID: PMC5012261.
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PeerJ. 2016 Aug 31;4:e2389. doi: 10.7717/peerj.2389. eCollection 2016.

Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose.

PeerJ

Wilasinee Suwanjang, Supaluk Prachayasittikul, Virapong Prachayasittikul

Affiliations

  1. Center for Research and Innovation, Faculty of Medical Technology, Mahidol University , Bangkok , Thailand.
  2. Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University , Bangkok , Thailand.
  3. Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University , Bangkok , Thailand.

PMID: 27635352 PMCID: PMC5012261 DOI: 10.7717/peerj.2389

Abstract

8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation, leading to cell death. Here, the effect of 8-hydroxyquinoline and derivatives (5-chloro-7-iodo-8-hydroxyquinoline or clioquinol and 8-hydroxy-5-nitroquinoline or nitroxoline) on calpain-dependent (calpain-calpastatin) pathways in human neuroblastoma (SH-SY5Y) cells was investigated. 8-Hydroxyquinoline and derivatives ameliorated high glucose toxicity in SH-SY5Y cells. The investigated compounds, particularly clioquinol, attenuated the increased expression of calpain, even under high-glucose conditions. 8-Hydroxyquinoline and derivatives thus adversely affected the promotion of neuronal cell death by high glucose via the calpain-calpastatin signaling pathways. These findings support the beneficial effects of 8-hydroxyquinolines for further therapeutic development.

Keywords: 8-Hydroxyquinoline; Calpain; Clioquinol; High glucose; Neuronal cells; Nitroxoline

Conflict of interest statement

The authors declare there are no competing interests.

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