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Rohde C, Agerbo E, Nielsen PR. Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia. Dement Geriatr Cogn Dis Extra. 2016;6(2):361-373doi: 10.1159/000448395.
Rohde, C., Agerbo, E., & Nielsen, P. R. (2016). Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia. Dementia and geriatric cognitive disorders extra, 6(2), 361-373. https://doi.org/10.1159/000448395
Rohde, Christopher, et al. "Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia." Dementia and geriatric cognitive disorders extra vol. 6,2 (2016): 361-373. doi: https://doi.org/10.1159/000448395
Rohde C, Agerbo E, Nielsen PR. Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia. Dement Geriatr Cogn Dis Extra. 2016 Aug 20;6(2):361-373. doi: 10.1159/000448395. eCollection 2016. PMID: 27703469; PMCID: PMC5040891.
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Dement Geriatr Cogn Dis Extra. 2016 Aug 20;6(2):361-373. doi: 10.1159/000448395. eCollection 2016.

Does Schizophrenia in Offspring Increase the Risk of Developing Alzheimer's Dementia.

Dementia and geriatric cognitive disorders extra

Christopher Rohde, Esben Agerbo, Philip Rising Nielsen

Affiliations

  1. National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
  2. National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; CIRRAU - Centre for Integrated Register-Based Research at Aarhus University, Aarhus, Denmark.
  3. National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.

PMID: 27703469 PMCID: PMC5040891 DOI: 10.1159/000448395

Abstract

BACKGROUND/AIMS: Prior studies have consistently found a higher risk of dementia in individuals with schizophrenia, but whether this is due to a common etiology between the disorders remains obscure. We wanted to elucidate this association by investigating whether schizophrenia in offspring increases the risk of Alzheimer's dementia.

METHODS: All individuals born between 1930 and 1953 were identified through national registers and followed from their 50th birthday until the date of Alzheimer's dementia, death or end of the study. Regressions were performed to evaluate the association between offspring with schizophrenia and Alzheimer's dementia.

RESULTS: Individuals with offspring with schizophrenia did not have an increased risk of Alzheimer's dementia [incidence rate ratio (IRR), 0.97; 95% CI, 0.88-1.07] compared to individuals with offspring without psychiatric contact. This finding remained stable when evaluating early-onset (IRR, 1.10; 95% CI, 0.91-1.31) and late-onset Alzheimer's dementia (IRR, 0.92; 95% CI, 0.88-1.07). Similar findings were made for vascular and unspecified dementia.

CONCLUSION: The finding of no familial coaggregation between schizophrenia and Alzheimer's dementia may suggest that no common etiology between the disorders exists. This may indicate that the excess risk of dementia in individuals with schizophrenia is a by-product of the higher rates of somatic comorbidity and adverse health risk factors among these individuals.

Keywords: Cohort study; Dementia; Etiology; Familial coaggregation; Psychiatric disorders

References

  1. Int Psychogeriatr. 2011 Jun;23(5):749-55 - PubMed
  2. Acta Psychiatr Scand. 2007 Nov;116(5):317-33 - PubMed
  3. Schizophr Res. 2008 Jul;102(1-3):1-18 - PubMed
  4. Schizophr Bull. 2009 Mar;35(2):383-402 - PubMed
  5. J Geriatr Psychiatry Neurol. 2013 Sep;26(3):131-7 - PubMed
  6. JAMA Psychiatry. 2015 Nov;72(11):1095-101 - PubMed
  7. Scand J Public Health. 2011 Jul;39(7 Suppl):54-7 - PubMed
  8. Lancet. 2005 Dec 17;366(9503):2112-7 - PubMed
  9. J Neuropsychiatry Clin Neurosci. 2004 Winter;16(1):57-62 - PubMed
  10. Scand J Public Health. 2011 Jul;39(7 Suppl):22-5 - PubMed
  11. Eur Neuropsychopharmacol. 2006 Dec;16(8):547-51 - PubMed
  12. Dement Geriatr Cogn Disord. 2007;24(3):220-8 - PubMed
  13. Psychoneuroendocrinology. 2014 Jan;39:1-10 - PubMed
  14. Dan Med J. 2013 Feb;60(2):A4578 - PubMed
  15. J Psychopharmacol. 2005 Nov;19(6 Suppl):47-55 - PubMed
  16. Br J Psychiatry. 2010 Jul;197(1):28-35 - PubMed
  17. J Neurol Neurosurg Psychiatry. 2005 Dec;76 Suppl 5:v2-7 - PubMed
  18. Psychiatr Q. 2012 Jun;83(2):127-44 - PubMed
  19. Psychol Med. 1999 May;29(3):697-701 - PubMed
  20. Am J Psychiatry. 2006 Mar;163(3):521-8 - PubMed
  21. Br J Psychiatry. 2003 Sep;183:213-9 - PubMed
  22. Arch Gen Psychiatry. 2000 Nov;57(11):1061-9 - PubMed
  23. Arch Gen Psychiatry. 1988 Oct;45(10):894-900 - PubMed
  24. J Psychiatr Res. 2013 Nov;47(11):1549-56 - PubMed
  25. Int J Geriatr Psychiatry. 2009 Jan;24(1):61-7 - PubMed
  26. Dement Geriatr Cogn Disord. 2015 ;39(1-2):105-15 - PubMed
  27. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1369-80 - PubMed
  28. Neurocase. 2010 Jun;16(3):273-9 - PubMed
  29. Eur Psychiatry. 1998 Dec;13(8):392-8 - PubMed
  30. BMC Fam Pract. 2009 May 09;10:32 - PubMed
  31. Eur Arch Psychiatry Clin Neurosci. 2002 Apr;252(2):93-7 - PubMed
  32. JAMA Psychiatry. 2015 Nov;72(11):1075-6 - PubMed
  33. Int J Geriatr Psychiatry. 2015 Feb;30(2):111-29 - PubMed
  34. Curr Alzheimer Res. 2014;11(7):681-93 - PubMed
  35. J Cereb Blood Flow Metab. 2016 Jan;36(1):172-86 - PubMed
  36. J Clin Psychiatry. 2007 Jun;68(6):899-907 - PubMed
  37. Neurology. 2013 May 7;80(19):1778-83 - PubMed
  38. Arch Gen Psychiatry. 2009 Jul;66(7):713-20 - PubMed
  39. Dement Geriatr Cogn Disord. 2011;32(5):342-50 - PubMed
  40. Epidemiol Rev. 2008;30:1-14 - PubMed
  41. ScientificWorldJournal. 2003 Jun 16;3:497-519 - PubMed
  42. Dialogues Clin Neurosci. 2008;10(3):345-57 - PubMed
  43. Lancet. 2015 Oct 24;386(10004):1698-706 - PubMed
  44. BMJ Open. 2013 Apr 17;3(4):null - PubMed
  45. Neurology. 1992 Aug;42(8):1481-8 - PubMed
  46. Int J Geriatr Psychiatry. 2015 Mar;30(3):234-46 - PubMed
  47. Scand J Public Health. 2011 Jul;39(7 Suppl):30-3 - PubMed
  48. Expert Opin Pharmacother. 2014 Sep;15(13):1797-810 - PubMed
  49. Dement Geriatr Cogn Disord. 2010;29(2):146-53 - PubMed

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