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Takemoto K, Ii M, Nishizuka SS. Importance of metabolic rate to the relationship between the number of genes in a functional category and body size in Peto's paradox for cancer. R Soc Open Sci. 2016;3(9):160267doi: 10.1098/rsos.160267.
Takemoto, K., Ii, M., & Nishizuka, S. S. (2016). Importance of metabolic rate to the relationship between the number of genes in a functional category and body size in Peto's paradox for cancer. Royal Society open science, 3(9), 160267. https://doi.org/10.1098/rsos.160267
Takemoto, Kazuhiro, et al. "Importance of metabolic rate to the relationship between the number of genes in a functional category and body size in Peto's paradox for cancer." Royal Society open science vol. 3,9 (2016): 160267. doi: https://doi.org/10.1098/rsos.160267
Takemoto K, Ii M, Nishizuka SS. Importance of metabolic rate to the relationship between the number of genes in a functional category and body size in Peto's paradox for cancer. R Soc Open Sci. 2016 Sep 07;3(9):160267. doi: 10.1098/rsos.160267. eCollection 2016 Sep. PMID: 27703689; PMCID: PMC5043308.
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R Soc Open Sci. 2016 Sep 07;3(9):160267. doi: 10.1098/rsos.160267. eCollection 2016 Sep.

Importance of metabolic rate to the relationship between the number of genes in a functional category and body size in Peto's paradox for cancer.

Royal Society open science

Kazuhiro Takemoto, Masato Ii, Satoshi S Nishizuka

Affiliations

  1. Department of Bioscience and Bioinformatics , Kyushu Institute of Technology , Iizuka, Fukuoka 820-8502 , Japan.
  2. Molecular Therapeutics Laboratory, Department of Surgery , Iwate Medical University School of Medicine , Morioka, Iwate 020-8505 , Japan.

PMID: 27703689 PMCID: PMC5043308 DOI: 10.1098/rsos.160267

Abstract

Elucidation of tumour suppression mechanisms is a major challenge in cancer biology. Therefore, Peto's paradox, or low cancer incidence in large animals, has attracted focus. According to the gene-abundance hypothesis, which considers the increase/decrease in cancer-related genes with body size, researchers evaluated the associations between gene abundance and body size. However, previous studies only focused on a few specific gene functions and have ignored the alternative hypothesis (metabolic rate hypothesis): in this hypothesis, the cellular metabolic rate and subsequent oxidative stress decreases with increasing body size. In this study, we have elected to explore the gene-abundance hypothesis taking into account the metabolic rate hypothesis. Thus, we comprehensively investigated the correlation between the number of genes in various functional categories and body size while at the same time correcting for the mass-specific metabolic rate (

Keywords: Peto's paradox; body size; cancer; functional analysis of genome; metabolic rate

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