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Lalitha V, Pal GK, Pal P, et al. Gender Difference in the Role of Posterodorsal Amygdala on the Regulation of Food Intake, Adiposity and Immunological Responses in Albino Wistar Rats. Ann Neurosci. 2016;23(1):6-12doi: 10.1159/000443550.
Lalitha, V., Pal, G. K., Pal, P., Parija, S. C., & Murugaiyan, S. B. (2016). Gender Difference in the Role of Posterodorsal Amygdala on the Regulation of Food Intake, Adiposity and Immunological Responses in Albino Wistar Rats. Annals of neurosciences, 23(1), 6-12. https://doi.org/10.1159/000443550
Lalitha, Venugopal, et al. "Gender Difference in the Role of Posterodorsal Amygdala on the Regulation of Food Intake, Adiposity and Immunological Responses in Albino Wistar Rats." Annals of neurosciences vol. 23,1 (2016): 6-12. doi: https://doi.org/10.1159/000443550
Lalitha V, Pal GK, Pal P, Parija SC, Murugaiyan SB. Gender Difference in the Role of Posterodorsal Amygdala on the Regulation of Food Intake, Adiposity and Immunological Responses in Albino Wistar Rats. Ann Neurosci. 2016 Mar;23(1):6-12. doi: 10.1159/000443550. Epub 2016 Mar 11. PMID: 27536016; PMCID: PMC4934414.
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Ann Neurosci. 2016 Mar;23(1):6-12. doi: 10.1159/000443550. Epub 2016 Mar 11.

Gender Difference in the Role of Posterodorsal Amygdala on the Regulation of Food Intake, Adiposity and Immunological Responses in Albino Wistar Rats.

Annals of neurosciences

Venugopal Lalitha, Gopal Krushna Pal, Pravati Pal, Subash Chandra Parija, Sathish Babu Murugaiyan

Affiliations

  1. Departments of Physiology, Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER), Puducherry, India.
  2. Microbiology, Jawaharlal Institute of Post-Graduate Medical Education and Research (JIPMER), Puducherry, India.
  3. Departments of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

PMID: 27536016 PMCID: PMC4934414 DOI: 10.1159/000443550

Abstract

Lesion of posterodorsal amygdala (PDA) has been known to produce hyperphagia and obesity in animal models. However, the influence of gender on food intake (FI), body weight (BW) and immunological parameters following PDA lesion is not yet known. The present work was carried out to study the effect of gender on the regulation of FI, BW and immunological parameters following lesions of PDA in albino Wistar rats. Twenty-four albino Wistar rats were divided equally into 2 groups - PDA group and control group - with 6 male and 6 female rats in each. In the experimental group, bilateral electrolytic lesion of the respective nuclei was performed by stereotaxy and post-lesion parameters were recorded. In the control group, sham lesion was made. Male-female difference in each parameter was determined. Following PDA lesion, FI increased significantly in both male (p < 0.001) and female rats (p < 0.01) but the percentage increase in FI was significantly more in female rats (p < 0.001). BW also increased in both the sexes but the increase in BW was significant only in male rats (p < 0.05). Both male and female rats showed increase in the concentration of cluster of differentiation 4 (CD4), but the significant increase in CD4 concentration (p < 0.01) was seen only in male rats. CD8 concentration increased significantly in male rats (p < 0.05). The liver weight-BW ratio was significantly greater in female rats (p < 0.001) following PDA lesions. Lesion of PDA results in accentuation of FI and BW gain and activation of immunity. There is a gender difference in the inhibitory control of PDA on FI, BW and immunity.

Keywords: Body weight; Cell-mediated immunity; Food intake; Humoral immunity; Posterodorsal amygdala

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