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Krzyzanowska MK, Walker-Dilks C, Atzema C, et al. Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline. Curr Oncol. 2016;23(4):280-5doi: 10.3747/co.23.3098.
Krzyzanowska, M. K., Walker-Dilks, C., Atzema, C., Morris, A., Gupta, R., Halligan, R., Kouroukis, T., & McCann, K. (2016). Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline. Current oncology (Toronto, Ont.), 23(4), 280-5. https://doi.org/10.3747/co.23.3098
Krzyzanowska, M K, et al. "Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline." Current oncology (Toronto, Ont.) vol. 23,4 (2016): 280-5. doi: https://doi.org/10.3747/co.23.3098
Krzyzanowska MK, Walker-Dilks C, Atzema C, Morris A, Gupta R, Halligan R, Kouroukis T, McCann K. Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline. Curr Oncol. 2016 Aug;23(4):280-5. doi: 10.3747/co.23.3098. Epub 2016 Aug 12. PMID: 27536179; PMCID: PMC4974036.
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Curr Oncol. 2016 Aug;23(4):280-5. doi: 10.3747/co.23.3098. Epub 2016 Aug 12.

Approach to fever assessment in ambulatory cancer patients receiving chemotherapy: a clinical practice guideline.

Current oncology (Toronto, Ont.)

M K Krzyzanowska, C Walker-Dilks, C Atzema, A Morris, R Gupta, R Halligan, T Kouroukis, K McCann

Affiliations

  1. University Health Network, Toronto, ON.
  2. Program in Evidence-Based Care, McMaster University, Hamilton, ON.
  3. Institute for Clinical Evaluative Sciences ( ices ), Toronto, ON.
  4. Mount Sinai Hospital, Toronto, ON.
  5. Windsor Regional Hospital, Windsor, Hamilton, ON.
  6. Grand River Hospital, Kitchener, Hamilton, ON.
  7. Juravinski Cancer Centre, Hamilton, ON.

PMID: 27536179 PMCID: PMC4974036 DOI: 10.3747/co.23.3098

Abstract

BACKGROUND: This guideline was prepared by the Fever Assessment Guideline Development Group, a group organized by the Program in Evidence-Based Care at the request of the Cancer Care Ontario Systemic Treatment Program. The mandate was to develop a standardized approach (in terms of definitions, information, and education) for the assessment of fever in cancer patients receiving chemotherapy.

METHODS: The guideline development methods included a search for existing guidelines, literature searches in medline and embase for systematic reviews and primary studies, internal review by content and methodology experts, and external review by targeted experts and intended users.

RESULTS: The search identified eight guidelines that had partial relevance to the topic of the present guideline and thirty-eight primary studies. The studies were mostly noncomparative prospective or retrospective studies. Few studies directly addressed the topic of fever except as one among many symptoms or adverse effects associated with chemotherapy. The recommendations concerning fever definition are supported mainly by other existing guidelines. No evidence was found that directly pertained to the assessment of fever before a diagnosis of febrile neutropenia was made. However, some studies evaluated approaches to symptom management that included fever among the symptoms. Few studies directly addressed information needs and resources for managing fever in cancer patients.

CONCLUSIONS: Fever in patients with cancer who are receiving systemic therapy is a common and potentially serious symptom that requires prompt assessment, but currently, evidence to inform best practices concerning when, where, and by whom that assessment is done is very limited.

Keywords: Fever; chemotherapy; febrile neutropenia

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