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Moubarz G, Embaby MA, Doleib NM, et al. Effect of dietary antioxidant supplementation (Cuminum cyminum) on bacterial susceptibility of diabetes-induced rats. Cent Eur J Immunol. 2016;41(2):132-7doi: 10.5114/ceji.2016.60985.
Moubarz, G., Embaby, M. A., Doleib, N. M., & Taha, M. M. (2016). Effect of dietary antioxidant supplementation (Cuminum cyminum) on bacterial susceptibility of diabetes-induced rats. Central-European journal of immunology, 41(2), 132-7. https://doi.org/10.5114/ceji.2016.60985
Moubarz, Gehan, et al. "Effect of dietary antioxidant supplementation (Cuminum cyminum) on bacterial susceptibility of diabetes-induced rats." Central-European journal of immunology vol. 41,2 (2016): 132-7. doi: https://doi.org/10.5114/ceji.2016.60985
Moubarz G, Embaby MA, Doleib NM, Taha MM. Effect of dietary antioxidant supplementation (Cuminum cyminum) on bacterial susceptibility of diabetes-induced rats. Cent Eur J Immunol. 2016;41(2):132-7. doi: 10.5114/ceji.2016.60985. Epub 2016 Jul 15. PMID: 27536197; PMCID: PMC4967646.
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Cent Eur J Immunol. 2016;41(2):132-7. doi: 10.5114/ceji.2016.60985. Epub 2016 Jul 15.

Effect of dietary antioxidant supplementation (Cuminum cyminum) on bacterial susceptibility of diabetes-induced rats.

Central-European journal of immunology

Gehan Moubarz, Mohamed A Embaby, Nada M Doleib, Mona M Taha

Affiliations

  1. Department of Chemistry, Faculty of Science and Arts-Khulais, King Abdulaziz University, Saudi Arabia; Environmental & Occupational Medicine Department, Environmental Research Division, National Research Centre, Egypt.
  2. Department of Chemistry, Faculty of Science and Arts-Khulais, King Abdulaziz University, Saudi Arabia; Food Toxicology and Contaminants Department, National Research Centre, Egypt.
  3. Department of Biology, Faculty of Science and Arts-Khulais, King Abdulaziz University, Saudi Arabia.
  4. Environmental & Occupational Medicine Department, Environmental Research Division, National Research Centre, Egypt.

PMID: 27536197 PMCID: PMC4967646 DOI: 10.5114/ceji.2016.60985

Abstract

Diabetic patients are at risk of acquiring infections. Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication. Diabetes causes generation of reactive oxygen species that increases oxidative stress, which may play a role in the development of complications as immune-deficiency and bacterial infection. The study aimed to investigate the role of a natural antioxidant, cumin, in the improvement of immune functions in diabetes. Diabetes was achieved by interperitoneal injection of streptozotocin (STZ). Bacterial infection was induced by application of Staphylococcus aureus suspension to a wound in the back of rats. The antioxidant was administered for 6 weeks. Results revealed a decrease in blood glucose levels in diabetic rats (p < 0.001), in addition to improving immune functions by decreasing total IgE approaching to the normal control level. Also, inflammatory cytokine (IL-6, IL-1β and TNF) levels, as well as total blood count decreased in diabetic rats as compared to the control group. Thus, cumin may serve as anti-diabetic treatment and may help in attenuating diabetic complications by improving immune functions. Therefore, a medical dietary antioxidant supplementation is important to improve the immune functions in diabetes.

Keywords: Cuminum cyminum; Staphylococcus aureus; diabetes; immunity; streptozotocin (STZ)

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