Display options
Cite
Scharl M, Bruckner RS, Rogler G. The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease. United European Gastroenterol J. 2016;4(4):506-14doi: 10.1177/2050640616635957.
Scharl, M., Bruckner, R. S., & Rogler, G. (2016). The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease. United European gastroenterology journal, 4(4), 506-14. https://doi.org/10.1177/2050640616635957
Scharl, Michael, et al. "The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease." United European gastroenterology journal vol. 4,4 (2016): 506-14. doi: https://doi.org/10.1177/2050640616635957
Scharl M, Bruckner RS, Rogler G. The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease. United European Gastroenterol J. 2016 Aug;4(4):506-14. doi: 10.1177/2050640616635957. Epub 2016 Feb 19. PMID: 27536360; PMCID: PMC4971795.
Copy Download .nbib Format: NLM
Share it on

United European Gastroenterol J. 2016 Aug;4(4):506-14. doi: 10.1177/2050640616635957. Epub 2016 Feb 19.

The two sides of the coin: Similarities and differences in the pathomechanisms of fistulas and stricture formations in irritable bowel disease.

United European gastroenterology journal

Michael Scharl, Ramona S Bruckner, Gerhard Rogler

Affiliations

  1. Division of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

PMID: 27536360 PMCID: PMC4971795 DOI: 10.1177/2050640616635957

Abstract

Fistulas and fibrosis or strictures represent frequent complications in irritable bowel disease (IBD) patients. To date, treatment options for fistulas are limited and surgery is often required. Similarly, no preventive treatment for fibrosis and stricture formation has been established. Frequently, stricture formation and fibrosis precede fistula formation, indicating that both processes may be connected or interrelated. Knowledge about the pathology of both processes is limited. A crucial role for the epithelial-to-mesenchymal transition (EMT) in fistula development has been demonstrated. Of note, EMT also plays a major role in the pathogenesis of fibrosis in many organs, and most likely also plays that role in the intestine. In addition, aberrant matrix remodeling, as well as soluble factors such as tumor necrosis factor (TNF), interleukin 13 (IL-13) and tumor growth factor beta (TGFβ) were involved, both in the onset of the fistula and fibrosis formation. Both fistulas and fibrosis may occur due to deregulated wound healing mechanisms from chronic and severe intestinal inflammation; however, further research is required to obtain a better understanding of the complex pathophysiology of fistula and intestinal fibrosis formation, to allow the development of new and more effective preventive treatment options for those important disease complications.

Keywords: Epithelial-mesenchymal transition; fibrosis; fistula; interleukin 13; irritable bowel disease; metalloproteinase; tumor growth factor beta; wound healing

References

  1. Inflamm Bowel Dis. 2011 Sep;17 (9):1907-16 - PubMed
  2. World J Gastrointest Pathophysiol. 2014 Aug 15;5(3):205-12 - PubMed
  3. Gastroenterology. 2003 Nov;125(5):1508-30 - PubMed
  4. J Crohns Colitis. 2014 Oct;8(10):1147-65 - PubMed
  5. PLoS One. 2013 Nov 08;8(11):e78882 - PubMed
  6. Sci Transl Med. 2013 Jun 19;5(190):190ps10 - PubMed
  7. Int J Colorectal Dis. 2009 May;24(5):521-6 - PubMed
  8. Int Arch Allergy Immunol. 2013;161(1):81-6 - PubMed
  9. Gut. 2013 Jan;62(1):63-72 - PubMed
  10. Gut. 2004 May;53(5):701-9 - PubMed
  11. Nat Rev Gastroenterol Hepatol. 2009 Apr;6(4):228-35 - PubMed
  12. Am J Gastroenterol. 2010 Mar;105(3):642-51 - PubMed
  13. J Clin Invest. 2009 Jun;119(6):1420-8 - PubMed
  14. Gastroenterology. 2007 Jan;132(1):52-65 - PubMed
  15. Arch Surg. 1986 Oct;121(10):1187-90 - PubMed
  16. Inflamm Bowel Dis. 2013 Dec;19(13):2878-87 - PubMed
  17. Clin Transl Med. 2015 Feb 07;4:1 - PubMed
  18. Gastroenterology. 2002 Apr;122(4):875-80 - PubMed
  19. Am J Gastroenterol. 2010 Feb;105(2):289-97 - PubMed
  20. Z Gastroenterol. 1989 Jun;27(6):313-6 - PubMed
  21. Eur J Immunol. 2014 Feb;44(2):370-85 - PubMed
  22. Dis Colon Rectum. 1996 Feb;39(2):136-42 - PubMed
  23. Gut. 2014 Sep;63(9):1381-92 - PubMed
  24. N Engl J Med. 1980 May 1;302(18):981-7 - PubMed
  25. Eur J Gastroenterol Hepatol. 2014 Jan;26(1):114-8 - PubMed
  26. World J Gastroenterol. 2012 Jul 28;18(28):3635-61 - PubMed
  27. Inflamm Bowel Dis. 2016 Jan;22(1):241-7 - PubMed
  28. J Gastrointest Surg. 2007 Apr;11(4):529-37 - PubMed
  29. PLoS One. 2012;7(12):e52332 - PubMed
  30. Inflamm Bowel Dis. 2011 Jan;17(1):202-12 - PubMed
  31. Digestion. 2012;85(3):202-9 - PubMed
  32. Gut. 2012 Apr;61(4):622-9 - PubMed
  33. Gastroenterol Clin North Am. 2004 Jun;33(2):421-54, xi-xii - PubMed
  34. Gastroenterology. 1984 Feb;86(2):249-66 - PubMed
  35. Inflamm Bowel Dis. 2002 Jul;8(4):244-50 - PubMed
  36. J Clin Invest. 2003 Dec;112(12):1776-84 - PubMed
  37. Gut. 1966 Apr;7(2):181-7 - PubMed
  38. J Pediatr Gastroenterol Nutr. 2013 Sep;57(3):401-12 - PubMed
  39. Gut. 2004 Sep;53(9):1314-21 - PubMed
  40. Int J Colorectal Dis. 1996;11(5):222-6 - PubMed
  41. J Crohns Colitis. 2016 Apr;10 (4):377-86 - PubMed
  42. Am J Dig Dis. 1966 Nov;11(11):865-80 - PubMed
  43. Gut. 1980 Jun;21(6):525-7 - PubMed
  44. Aliment Pharmacol Ther. 2008 Sep 1;28(5):545-56 - PubMed
  45. N Engl J Med. 2004 Feb 26;350(9):876-85 - PubMed
  46. Inflamm Bowel Dis. 2008 Nov;14(11):1514-27 - PubMed
  47. Gut. 2007 Jan;56(1):130-9 - PubMed
  48. Am J Gastroenterol. 2007 Feb;102(2):439-48 - PubMed

Publication Types