Display options
Cite
Jacob N, Targan SR, Shih DQ. Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterol J. 2016;4(4):531-40doi: 10.1177/2050640616649356.
Jacob, N., Targan, S. R., & Shih, D. Q. (2016). Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European gastroenterology journal, 4(4), 531-40. https://doi.org/10.1177/2050640616649356
Jacob, Noam, et al. "Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD." United European gastroenterology journal vol. 4,4 (2016): 531-40. doi: https://doi.org/10.1177/2050640616649356
Jacob N, Targan SR, Shih DQ. Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterol J. 2016 Aug;4(4):531-40. doi: 10.1177/2050640616649356. Epub 2016 May 10. PMID: 27536363; PMCID: PMC4971798.
Copy Download .nbib Format: NLM
Share it on

United European Gastroenterol J. 2016 Aug;4(4):531-40. doi: 10.1177/2050640616649356. Epub 2016 May 10.

Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD.

United European gastroenterology journal

Noam Jacob, Stephan R Targan, David Q Shih

Affiliations

  1. F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Division of Digestive Diseases, Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  2. F. Widjaja Foundation, Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

PMID: 27536363 PMCID: PMC4971798 DOI: 10.1177/2050640616649356

Abstract

The frequency of fibrosing Crohn's disease (CD) is significant, with approximately 40% of CD patients with ileal disease developing clinically apparent strictures throughout their lifetime. Although strictures may be subdivided into fibrotic, inflammatory, or mixed forms, despite immunosuppressive therapy in CD patients in the form of steroids or immunomodulators, the frequency of fibrostenosing complications has still remained significant. A vast number of genetic and epigenetic variables are thought to contribute to fibrostenosing disease, including those that affect cytokine biology, and therefore highlight the complexity of disease, but also shed light on targetable pathways. Exclusively targeting fibrosis may be difficult, however, because of the relatively slow evolution of fibrosis in CD, and the potential adverse effects of inhibiting pathways involved in tissue repair and mucosal healing. Acknowledging these caveats, cytokine-targeted therapy has become the mainstay of treatment for many inflammatory conditions and is being evaluated for fibrotic disorders. The question of whether anti-cytokine therapy will prove useful for intestinal fibrosis is, therefore, acutely relevant. This review will highlight some of the current therapeutics targeting cytokines involved in fibrosis.

Keywords: Crohn’s disease; Fibrosis; IBD; cytokine; inflammation

References

  1. Lab Invest. 2008 Sep;88(9):973-85 - PubMed
  2. Mucosal Immunol. 2011 Mar;4(2):172-85 - PubMed
  3. Liver Int. 2009 Aug;29(7):997-1009 - PubMed
  4. Immunol Res. 2004;30(3):339-49 - PubMed
  5. Circ Res. 2010 May 28;106(10):1646-55 - PubMed
  6. J Clin Invest. 2015 Jul 1;125(7):2795-807 - PubMed
  7. Immunity. 2002 Mar;16(3):479-92 - PubMed
  8. Am J Pathol. 2010 Dec;177(6):2837-49 - PubMed
  9. J Biol Chem. 2005 Mar 18;280(11):10055-64 - PubMed
  10. Int J Colorectal Dis. 2006 Apr;21(3):276-81 - PubMed
  11. Dig Dis Sci. 2001 Jul;46(7):1520-5 - PubMed
  12. Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G1035-44 - PubMed
  13. FASEB J. 2002 Jul;16(9):963-74 - PubMed
  14. Kidney Int. 2005 May;67(5):1812-20 - PubMed
  15. Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G845-50 - PubMed
  16. Eur J Clin Invest. 2009 Feb;39(2):145-56 - PubMed
  17. Gastroenterology. 2012 Sep;143(3):765-76.e1-3 - PubMed
  18. J Mol Cell Cardiol. 2014 Nov;76:148-57 - PubMed
  19. J Immunol. 2007 Apr 1;178(7):4033-8 - PubMed
  20. Kidney Int. 1999 Dec;56(6):2116-27 - PubMed
  21. PLoS One. 2011 Jan 11;6(1):e16090 - PubMed
  22. Gut. 2012 Dec;61(12):1693-700 - PubMed
  23. J Biol Chem. 2005 Oct 28;280(43):36099-109 - PubMed
  24. N Engl J Med. 2014 May 29;370(22):2083-92 - PubMed
  25. Gastroenterology. 2011 May;140(6):1785-94 - PubMed
  26. Inflamm Bowel Dis. 2013 Dec;19(13):2829-39 - PubMed
  27. J Intern Med. 2008 Jun;263(6):584-90 - PubMed
  28. Ann Rheum Dis. 2009 Sep;68(9):1433-9 - PubMed
  29. J Biol Chem. 2003 Oct 31;278(44):43470-9 - PubMed
  30. Respiration. 2008;75(3):346-9 - PubMed
  31. Inflamm Bowel Dis. 2013 Mar;19(3):526-33 - PubMed
  32. Genes Dev. 2000 Jan 15;14(2):187-97 - PubMed
  33. Lab Invest. 2013 Jul;93(7):801-11 - PubMed
  34. Can J Gastroenterol. 2012 Jan;26(1):33-9 - PubMed
  35. Science. 1996 Nov 8;274(5289):990-2 - PubMed
  36. Mol Med Rep. 2015 May;11(5):3808-13 - PubMed
  37. Am J Pathol. 2003 Apr;162(4):1355-60 - PubMed
  38. Gastroenterology. 2008 Dec;135(6):2003-13, 2013.e1-7 - PubMed
  39. Aliment Pharmacol Ther. 2009 Feb 1;29(3):279-85 - PubMed
  40. Inflamm Bowel Dis. 2008 Feb;14(2):213-6 - PubMed
  41. Immunity. 2008 Jul 18;29(1):79-89 - PubMed
  42. Kidney Int. 2006 Oct;70(7):1234-43 - PubMed
  43. J Cell Physiol. 1987 Feb;130(2):270-5 - PubMed
  44. Curr Drug Targets. 2010 Feb;11(2):242-8 - PubMed
  45. Eur J Immunol. 2014 Feb;44(2):370-85 - PubMed
  46. Am J Gastroenterol. 2006 May;101(5):1030-8 - PubMed
  47. Gastroenterology. 2007 Jul;133(1):137-49 - PubMed
  48. J Immunol. 2011 Sep 15;187(6):3003-14 - PubMed
  49. Nature. 1996 Nov 28;384(6607):372-5 - PubMed
  50. J Exp Med. 1999 Oct 4;190(7):995-1004 - PubMed
  51. J Exp Med. 2008 May 12;205(5):1049-62 - PubMed
  52. J Biol Chem. 2003 Oct 3;278(40):39251-8 - PubMed
  53. J Allergy Clin Immunol. 2003 Apr;111(4):677-90; quiz 691 - PubMed
  54. Lancet. 2011 May 21;377(9779):1760-9 - PubMed
  55. Gut. 2011 Sep;60(9):1178-81 - PubMed
  56. Ann Surg. 2005 Dec;242(6):880-7, discussion 887-9 - PubMed
  57. Gene. 1997 Dec 19;204(1-2):35-46 - PubMed
  58. Lancet. 2009 Jul 18;374(9685):222-8 - PubMed
  59. Am J Pathol. 2012 Feb;180(2):636-49 - PubMed
  60. Gastroenterology. 1990 Jun;98(6):1543-8 - PubMed
  61. PLoS One. 2012;7(12):e52332 - PubMed
  62. Cell Mol Life Sci. 2015 May;72(10):2023-39 - PubMed
  63. Fibrogenesis Tissue Repair. 2013 Jul 08;6(1):13 - PubMed
  64. Hepatology. 1998 Dec;28(6):1607-15 - PubMed
  65. J Biol Chem. 2011 Feb 11;286(6):4485-92 - PubMed
  66. J Pathol. 2011 Aug;224(4):461-72 - PubMed
  67. Arthritis Rheum. 2007 Jan;56(1):323-33 - PubMed
  68. FASEB J. 2004 May;18(7):816-27 - PubMed
  69. Dig Dis Sci. 2012 Feb;57(2):335-44 - PubMed
  70. Gastroenterology. 2000 Jun;118(6):1149-56 - PubMed
  71. Nat Med. 2006 Jan;12(1):99-106 - PubMed
  72. Semin Immunopathol. 2014 Sep;36(5):541-51 - PubMed
  73. Immunity. 1997 Jan;6(1):79-88 - PubMed
  74. Biochem Biophys Res Commun. 2015 Dec 25;468(4):554-60 - PubMed
  75. J Biol Chem. 2000 May 19;275(20):15220-5 - PubMed
  76. Exp Lung Res. 1995 Sep-Oct;21(5):791-808 - PubMed
  77. J Clin Invest. 1999 Sep;104(6):777-85 - PubMed
  78. Mol Cell Biol. 2001 May;21(10):3451-61 - PubMed
  79. Kidney Int. 1998 Jul;54(1):99-109 - PubMed
  80. Gut. 2009 Jun;58(6):777-89 - PubMed
  81. Br J Haematol. 2001 Jul;114(1):111-3 - PubMed
  82. Clin Exp Rheumatol. 2007 Jan-Feb;25(1):23-8 - PubMed
  83. PLoS One. 2009;4(3):e4719 - PubMed
  84. Ann Surg. 2010 Aug;252(2):307-12 - PubMed
  85. Nature. 1995 Aug 17;376(6541):594-6 - PubMed
  86. Inflamm Bowel Dis. 2007 Nov;13(11):1333-8 - PubMed
  87. Gastroenterology. 2010 Jan;138(1):285-93 - PubMed
  88. Thorax. 2006 Oct;61(10):886-94 - PubMed
  89. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8441-6 - PubMed
  90. Br J Surg. 2009 May;96(5):541-51 - PubMed
  91. Inflammation. 2008 Aug;31(4):215-21 - PubMed
  92. J Lab Clin Med. 1995 Jun;125(6):779-85 - PubMed
  93. J Biol Chem. 2010 Jun 25;285(26):20202-12 - PubMed
  94. World J Gastroenterol. 2012 Aug 7;18(29):3790-9 - PubMed
  95. Gastroenterology. 2003 Jul;125(1):178-91 - PubMed
  96. Immunity. 1998 Aug;9(2):267-76 - PubMed
  97. J Am Soc Nephrol. 2008 May;19(5):953-60 - PubMed
  98. Mucosal Immunol. 2014 Nov;7(6):1492-503 - PubMed
  99. World J Gastroenterol. 2013 Jul 7;19(25):3931-41 - PubMed
  100. Nat Rev Immunol. 2004 Aug;4(8):583-94 - PubMed
  101. Inflamm Bowel Dis. 2004 Sep;10(5):536-45 - PubMed
  102. J Clin Invest. 1998 May 15;101(10):2129-39 - PubMed
  103. Dig Dis Sci. 2002 Jan;47(1):157-61 - PubMed
  104. BMC Nephrol. 2015 Jul 22;16:111 - PubMed

Publication Types