Display options
Cite
Hara D, Maki F, Tanaka S, et al. MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy. Cerebellum Ataxias. 2016;3:14doi: 10.1186/s40673-016-0052-4.
Hara, D., Maki, F., Tanaka, S., Sasaki, R., & Hasegawa, Y. (2016). MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy. Cerebellum & ataxias, 314. https://doi.org/10.1186/s40673-016-0052-4
Hara, Daisuke, et al. "MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy." Cerebellum & ataxias vol. 3 (2016): 14. doi: https://doi.org/10.1186/s40673-016-0052-4
Hara D, Maki F, Tanaka S, Sasaki R, Hasegawa Y. MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy. Cerebellum Ataxias. 2016 Aug 17;3:14. doi: 10.1186/s40673-016-0052-4. eCollection 2016. PMID: 27536377; PMCID: PMC4987966.
Copy Download .nbib Format: NLM
Share it on

Cerebellum Ataxias. 2016 Aug 17;3:14. doi: 10.1186/s40673-016-0052-4. eCollection 2016.

MRI-based cerebellar volume measurements correlate with the International Cooperative Ataxia Rating Scale score in patients with spinocerebellar degeneration or multiple system atrophy.

Cerebellum & ataxias

Daisuke Hara, Futaba Maki, Shigeaki Tanaka, Rie Sasaki, Yasuhiro Hasegawa

Affiliations

  1. Department of Internal Medicine, Division of Neurology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa 216-8511 Japan.

PMID: 27536377 PMCID: PMC4987966 DOI: 10.1186/s40673-016-0052-4

Abstract

BACKGROUND: Progression of clinical symptoms and cerebellar atrophy may vary among subtypes of spinocerebellar degeneration and multiple system atrophy. The aim of this cross-sectional study was to demonstrate the relationship between the International Cooperative Ataxia Rating Scale (ICARS) score and cerebellar volume derived from magnetic resonance imaging (MRI) in a broad spectrum of Japanese patients with cerebellar ataxia.

METHODS: A total of 86 patients with cerebellar ataxia (18 with cortical cerebellar atrophy, 34 with spinocerebellar ataxia, and 34 with multiple system atrophy) and 30 healthy subjects were studied. MRI-based cerebellar volume measurements were performed in all subjects using T1-weighted images acquired with a 1.5-T MRI scanner. The cerebellar volume/cranial anteroposterior (AP) diameter was used for statistical analysis.

RESULTS: Stepwise multiple regression analyses demonstrated that cerebellar volume/cranial AP diameter and midbrain AP/cranial AP diameter were significantly associated with the total score and domain I sub-score of ICARS. We found no interactions between these two anatomical factors in the ICARS total and domain I sub-scores. The main effects of these two predictors were statistically significant both in total and domain I sub-scores (p = 0.001 and 0.022, respectively).

CONCLUSIONS: Cerebellar volume and midbrain AP diameter normalized to the cranial AP diameter were significantly correlated with the ICARS total and domain I sub-scores. Further longitudinal studies are warranted to explore the role of these MRI biomarkers for predicting disease progression.

Keywords: Cerebellar volume; MRI; Multiple system atrophy; Spinocerebellar degeneration

References

  1. Psychiatry Res. 2011 Aug 30;193(2):123-30 - PubMed
  2. AJNR Am J Neuroradiol. 2011 May;32(5):890-7 - PubMed
  3. Neurobiol Aging. 2012 Dec;33(12):2774-81 - PubMed
  4. J Neuroimaging. 2014 May-Jun;24(3):250-6 - PubMed
  5. Neurology. 2008 Aug 26;71(9):670-6 - PubMed
  6. Cerebellum. 2012 Mar;11(1):272-9 - PubMed
  7. Ann Acad Med Singapore. 2005 Oct;34(9):553-7 - PubMed
  8. Ann Neurol. 1996 Apr;39(4):490-9 - PubMed
  9. Mov Disord. 2010 Sep 15;25(12):1953-9 - PubMed
  10. Brain. 2013 Mar;136(Pt 3):905-17 - PubMed
  11. Bull Tokyo Dent Coll. 2006 Nov;47(4):149-56 - PubMed
  12. Arch Neurol. 1998 Oct;55(10):1348-52 - PubMed
  13. J Parkinsons Dis. 2012;2(1):7-18 - PubMed
  14. Neurology. 2011 Sep 13;77(11):1035-41 - PubMed
  15. Cerebellum. 2008;7(2):189-97 - PubMed
  16. AJNR Am J Neuroradiol. 2003 Apr;24(4):644-7 - PubMed
  17. J Comp Neurol. 1996 Aug 5;371(4):537-51 - PubMed
  18. Neuroimage. 2008 Oct 15;43(1):10-9 - PubMed
  19. Eur J Epidemiol. 2011 Aug;26(8):657-86 - PubMed
  20. Clin Rehabil. 2015 Jan;29(1):69-79 - PubMed
  21. Brain. 2002 May;125(Pt 5):961-8 - PubMed
  22. Brain. 2015 May;138(Pt 5):1182-97 - PubMed
  23. Ann Neurol. 1999 Jan;45(1):65-74 - PubMed
  24. Neurobiol Aging. 2010 Aug;31(8):1401-18 - PubMed
  25. J Neurol Sci. 1997 Feb 12;145(2):205-11 - PubMed
  26. Mov Disord. 2006 Oct;21(10):1674-81 - PubMed
  27. Neurology. 2006 Jun 13;66(11):1717-20 - PubMed
  28. Neurology. 2015 Jul 7;85(1):96-103 - PubMed
  29. Childs Nerv Syst. 2008 Oct;24(10 ):1123-45 - PubMed
  30. Brain. 2004 Jan;127(Pt 1):175-81 - PubMed
  31. Cereb Cortex. 1999 Oct-Nov;9(7):712-21 - PubMed
  32. Brain. 2002 May;125(Pt 5):1070-83 - PubMed
  33. Mov Disord. 2004 Dec;19(12):1391-402 - PubMed
  34. Neuroimage. 2010 Jan 1;49(1):158-68 - PubMed
  35. Brain. 1998 Sep;121 ( Pt 9):1687-93 - PubMed
  36. Brain Imaging Behav. 2016 Mar;10 (1):252-7 - PubMed
  37. Mov Disord. 2006 May;21(5):699-704 - PubMed

Publication Types