Display options
Cite
Cho YJ, Chun YS, Rhyu KH, et al. Does the Time of Postoperative Bisphosphonate Administration Affect the Bone Union in Osteoporotic Intertrochanteric Fracture of Femur?. Hip Pelvis. 2015;27(4):258-64doi: 10.5371/hp.2015.27.4.258.
Cho, Y. J., Chun, Y. S., Rhyu, K. H., Kang, J. S., Jung, G. Y., & Lee, J. H. (2015). Does the Time of Postoperative Bisphosphonate Administration Affect the Bone Union in Osteoporotic Intertrochanteric Fracture of Femur?. Hip & pelvis, 27(4), 258-64. https://doi.org/10.5371/hp.2015.27.4.258
Cho, Yoon Je, et al. "Does the Time of Postoperative Bisphosphonate Administration Affect the Bone Union in Osteoporotic Intertrochanteric Fracture of Femur?." Hip & pelvis vol. 27,4 (2015): 258-64. doi: https://doi.org/10.5371/hp.2015.27.4.258
Cho YJ, Chun YS, Rhyu KH, Kang JS, Jung GY, Lee JH. Does the Time of Postoperative Bisphosphonate Administration Affect the Bone Union in Osteoporotic Intertrochanteric Fracture of Femur?. Hip Pelvis. 2015 Dec;27(4):258-64. doi: 10.5371/hp.2015.27.4.258. Epub 2015 Dec 30. PMID: 27536634; PMCID: PMC4972797.
Copy Download .nbib Format: NLM
Share it on

Hip Pelvis. 2015 Dec;27(4):258-64. doi: 10.5371/hp.2015.27.4.258. Epub 2015 Dec 30.

Does the Time of Postoperative Bisphosphonate Administration Affect the Bone Union in Osteoporotic Intertrochanteric Fracture of Femur?.

Hip & pelvis

Yoon Je Cho, Young Soo Chun, Kee Hyung Rhyu, Joon Soon Kang, Gwang Young Jung, Jun Hee Lee

Affiliations

  1. Department of Orthopedic Surgery, Kyung Hee University School of Medicine, Seoul, Korea.
  2. Department of Orthopedic Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
  3. Department of Orthopedic Surgery, Inha University College of Medicine, Incheon, Korea.

PMID: 27536634 PMCID: PMC4972797 DOI: 10.5371/hp.2015.27.4.258

Abstract

PURPOSE: This study was designed to investigate the effect of bisphosphonate administration starting time on bone healing and to identify the best administration time following surgical treatment of osteoporotic intertrochanteric fractures.

MATERIALS AND METHODS: Two hundreds and eighty four patients (284 hips; 52 males, 232 females) who underwent surgery following osteoporotic intertrochanteric fracture from December 2002 to December 2012 were retrospectively analyzed. The average follow-up period was 68.4 months. The patients were divided into three groups according to the time of bisphosphonate administration after operation: 1 week (group A; n=102), 1 month (group B; n=89), and 3 months (group C; n=93). Koval scores and change of Koval scores 1 year after operation were used for clinical evaluation. For radiologic evaluation, the time of callus appearance across the fracture line on sagittal and coronal radiographs and the time to absence of pain during hip motion was judged as the time of bone union.

RESULTS: Koval scores one year after surgery for groups A, B, and C were 2.44, 2.36, and 2.43 (P=0.895), respectively. The mean time of union was 12.4, 11.9, and 12.3 weeks after operation in the three groups (P=0.883), respectively. There were zero cases of nonunion. There were 3, 5, and 7 cases of fixative displacement in the three groups, respectively, but the distribution showed no significant difference (P>0.472).

CONCLUSION: The initiating time of bisphosphonate administration following surgery does not affect the clinical outcomes in patients with osteoporotic intertrochanteric fracture.

Keywords: Bisphosphonates; Bone healing; Intertrochanteric fractures; Osteoporotic fractures

References

  1. Eur Spine J. 2007 Apr;16(4):557-62 - PubMed
  2. Ann Oncol. 1994;5 Suppl 7:S53-5 - PubMed
  3. Clin Orthop Relat Res. 2010 Dec;468(12 ):3393-8 - PubMed
  4. Krankenpfl J. 2004;42(7-10):232 - PubMed
  5. J Bone Miner Res. 2014 Jan;29(1):1-23 - PubMed
  6. Yonsei Med J. 2007 Aug 31;48(4):645-52 - PubMed
  7. Osteoporos Int. 2015 Apr;26(4):1251-60 - PubMed
  8. J Bone Joint Surg Am. 2012 Oct 3;94(19):1729-36 - PubMed
  9. J Bone Miner Res. 2009 Jun;24(6):1095-102 - PubMed
  10. J Bone Miner Res. 1990 Jan;5(1):31-40 - PubMed
  11. N Z Med J. 2001 Jul 27;114(1136):329-32 - PubMed
  12. Bone. 2010 Aug;47(2):378-87 - PubMed
  13. J Orthop Res. 2005 Sep;23(5):1029-34 - PubMed
  14. J Bone Miner Res. 2001 Mar;16(3):429-36 - PubMed
  15. J Bone Miner Res. 2005 Nov;20(11):2044-52 - PubMed
  16. Bone. 1995 Aug;17(2):137-44 - PubMed
  17. Osteoporos Int. 2009 Jun;20(6):895-901 - PubMed
  18. J Bone Miner Res. 1999 Jun;14 (6):969-79 - PubMed
  19. J Bone Miner Res. 2004 Nov;19(11):1779-86 - PubMed
  20. J Hand Surg Am. 2009 Apr;34(4):595-602 - PubMed
  21. J Pharmacol Toxicol Methods. 2004 Jul-Aug;50(1):25-34 - PubMed
  22. J Am Acad Orthop Surg. 1994 May;2(3):150-156 - PubMed
  23. J Bone Joint Surg Br. 2005 Mar;87(3):416-20 - PubMed
  24. Biomater Med Devices Artif Organs. 1979;7(2):243-55 - PubMed
  25. J Transl Med. 2013 Dec 11;11:303 - PubMed
  26. Clin Endocrinol (Oxf). 2010 Feb;72(2):161-8 - PubMed
  27. J Bone Joint Surg Am. 2002 Aug;84-A(8):1342-8 - PubMed
  28. J Trauma. 2011 Jul;71(1):186-90 - PubMed

Publication Types