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Meng XM, Tang PM, Li J, et al. Macrophage Phenotype in Kidney Injury and Repair. Kidney Dis (Basel). 2015;1(2):138-46doi: 10.1159/000431214.
Meng, X. M., Tang, P. M., Li, J., & Lan, H. Y. (2015). Macrophage Phenotype in Kidney Injury and Repair. Kidney diseases (Basel, Switzerland), 1(2), 138-46. https://doi.org/10.1159/000431214
Meng, Xiao-Ming, et al. "Macrophage Phenotype in Kidney Injury and Repair." Kidney diseases (Basel, Switzerland) vol. 1,2 (2015): 138-46. doi: https://doi.org/10.1159/000431214
Meng XM, Tang PM, Li J, Lan HY. Macrophage Phenotype in Kidney Injury and Repair. Kidney Dis (Basel). 2015 Sep;1(2):138-46. doi: 10.1159/000431214. Epub 2015 Aug 07. PMID: 27536674; PMCID: PMC4934816.
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Kidney Dis (Basel). 2015 Sep;1(2):138-46. doi: 10.1159/000431214. Epub 2015 Aug 07.

Macrophage Phenotype in Kidney Injury and Repair.

Kidney diseases (Basel, Switzerland)

Xiao-Ming Meng, Patrick Ming-Kuen Tang, Jun Li, Hui Yao Lan

Affiliations

  1. School of Pharmacy, Anhui Medical University, Hefei, China.
  2. Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China.
  3. Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China.

PMID: 27536674 PMCID: PMC4934816 DOI: 10.1159/000431214

Abstract

BACKGROUND: Glomerular and interstitial macrophage infiltration is a feature for both the acute and chronic kidney diseases. Macrophages have been shown to play a diverse role in kidney injury and repair. Thus, macrophages may be a key cell type in acute and chronic kidney injury and repair.

SUMMARY AND KEY MESSAGES: During renal inflammation, circulating monocytes are recruited and then become activated and polarized. By adapting to the local microenvironment, macrophages can differentiate into different phenotypes and function as a double-bladed sword in different stages of kidney disease. In general, M1 macrophages play a pathogenic role in boosting inflammatory renal injury, whereas M2 macrophages exert an anti-inflammatory and wound healing (or profibrotic) role during renal repair. In this review, we highlight the phenotypic polarization of macrophages in renal diseases and dissect their distinct functions in renal injury and repair processes, respectively. Moreover, the current understanding of regulatory mechanisms on the phenotypic switch and macrophage-related therapy are also intensively discussed.

Keywords: Fibrosis; Inflammation; Macrophage; Phenotype

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