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Ban MJ, Park JH, Kim JW, et al. The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application. Clin Exp Otorhinolaryngol. 2016;10(4):349-356doi: 10.21053/ceo.2016.00941.
Ban, M. J., Park, J. H., Kim, J. W., Park, K. N., Lee, J. Y., Kim, H. K., & Lee, S. W. (2017). The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application. Clinical and experimental otorhinolaryngology, 10(4), 349-356. https://doi.org/10.21053/ceo.2016.00941
Ban, Myung Jin, et al. "The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application." Clinical and experimental otorhinolaryngology vol. 10,4 (2017): 349-356. doi: https://doi.org/10.21053/ceo.2016.00941
Ban MJ, Park JH, Kim JW, Park KN, Lee JY, Kim HK, Lee SW. The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application. Clin Exp Otorhinolaryngol. 2017 Dec;10(4):349-356. doi: 10.21053/ceo.2016.00941. Epub 2016 Sep 27. PMID: 27671715; PMCID: PMC5678041.
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Clin Exp Otorhinolaryngol. 2017 Dec;10(4):349-356. doi: 10.21053/ceo.2016.00941. Epub 2016 Sep 27.

The Efficacy of Fibroblast Growth Factor for the Treatment of Chronic Vocal Fold Scarring: From Animal Model to Clinical Application.

Clinical and experimental otorhinolaryngology

Myung Jin Ban, Jae Hong Park, Jae Wook Kim, Ki Nam Park, Jae Yong Lee, Hee Kyung Kim, Seung Won Lee

Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan, Korea.
  2. Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.
  3. Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.
  4. Department of Pathology, Soonchunhyang University College of Medicine, Bucheon, Korea.

PMID: 27671715 PMCID: PMC5678041 DOI: 10.21053/ceo.2016.00941

Abstract

OBJECTIVES: This study assessed the regenerative efficacy of basic fibroblast growth factor (FGF) in a rabbit model of chronic vocal fold scarring and then confirmed its utility and safety in a prospective trial of patients with this condition.

METHODS: FGF was injected three times, at 1-week intervals, into a chronic vocal fold scar created in a rabbit model. After 1 month, mRNA level of procollagen I, hyaluronic acid synthetase 2 (HAS 2), and matrix metalloproteinase 2 (MMP 2) were analyzed by real-time polymerase chain reaction. The relative densities of hyaluronic acid (HA) and collagen were examined 3 months post-injection. From April 2012 to September 2014, a prospective clinical trial was conducted at a tertiary hospital in Korea. FGF was injected into the mild vocal fold scar of 17 consecutive patients with a small glottic gap. The patients underwent perceptual, stroboscopic, acoustic aerodynamic test, and Voice Handicap Index (VHI) survey prior to and 3, 6, and 12 months after FGF injection.

RESULTS: FGF injection of the vocal fold scar decreased the density of collagen and increased mRNA level of HAS 2 and MMP 2 expression significantly compared to the control group injected with phosphate buffered solution in a rabbit model (P<0.05). In the clinical trial, significant improvements in the majority of the subjective and objective voice parameters were registered 3 months after FGF injection and were maintained at 12 months. Complications associated with the FGF injections, such as granuloma, were not observed during the follow-up period.

CONCLUSION: Based on the animal model and the prospective clinical trial, vocal fold injections of FGF in patients with mild chronic vocal fold scarring can significantly improve voice quality for as long as 1 year and without side effects. Our results recommend the use of FGF vocal fold injection as an alternative treatment modality for mild chronic vocal fold scarring.

Keywords: Dysphonia; Fibroblast Growth Factors; Vocal Cord

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